<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Solow, D.</style></author><author><style face="normal" font="default" size="100%">Burnetas, AN</style></author><author><style face="normal" font="default" size="100%">Roeder, T.</style></author><author><style face="normal" font="default" size="100%">Greenspan, N.S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolutionary consequences of selected locus-specific variations in epistasis and fitness contribution in Kauffman's NK model</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Theoretical Biology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alleles</style></keyword><keyword><style  face="normal" font="default" size="100%">article</style></keyword><keyword><style  face="normal" font="default" size="100%">computer simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">epistasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Evolution</style></keyword><keyword><style  face="normal" font="default" size="100%">gene locus</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome</style></keyword><keyword><style  face="normal" font="default" size="100%">mathematical model</style></keyword><keyword><style  face="normal" font="default" size="100%">Models</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">priority journal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sensitivity and Specificity</style></keyword><keyword><style  face="normal" font="default" size="100%">Variation (Genetics)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1999</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033590467&amp;doi=10.1006%2fjtbi.1998.0832&amp;partnerID=40&amp;md5=f40e172c93962491fc59ab58e5716ed4</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">196</style></volume><pages><style face="normal" font="default" size="100%">181-196</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Mathematical analysis and computer simulations are used to evaluate three modifications to Kauffman's NK model in an attempt to incorporate unexplored aspects of epistatic interaction between loci in genome evolution. Two modifications - one to the amount and the other to the distribution of epistatic interaction - further support Kauffman's conclusion that high levels of epistatic interaction lead to a decrease in overall fitness of the genome. The third model, however, provides a condition under which increased epistatic interaction at certain loci results in higher genome fitness.</style></abstract><notes><style face="normal" font="default" size="100%">cited By 7</style></notes></record></records></xml>