@article {13292,
	title = {Platelet-rich plasma ultrasound-guided injection in the treatment of carpal tunnel syndrome: A placebo-controlled clinical study.},
	journal = {J Tissue Eng Regen Med},
	volume = {12},
	year = {2018},
	month = {2018 Mar},
	pages = {e1480-e1488},
	abstract = {The purpose of this study is to demonstrate whether and to what extent a single injection of platelet-rich plasma (PRP), under ultrasound guidance, can improve the clinical symptoms of patients with a mild to moderate carpal tunnel syndrome (CTS). We conducted a prospective, randomized, clinical study including 50 patients suffering from mild to moderate CTS for a minimum duration of 3~months. Patients were randomly divided into 2 groups: Group A (26 patients) received an ultrasound-guided PRP injection into the carpal tunnel, whereas Group B (24 patients) was injected with placebo (0.9\% normal saline). The short- and mid-term outcomes were determined with the use of the Q-DASH questionnaire and the pain scale VAS administered at 0, 4, and 12~weeks follow-up. The success ratio was determined by the difference in the Q-DASH obtained pre-injection minus the final Q-DASH obtained after 12~weeks follow-up. Success was defined as a difference more than 25\%. Group A patients demonstrated a 76.9\% success as determined by the difference Q-DASH, whereas Group B patients demonstrated 33.3\% success, which was significantly less than Group A (Χ , p~=~.011). The findings of this study suggest that a single PRP ultrasound-guided injection has positive effects in patients with CTS.},
	issn = {1932-7005},
	doi = {10.1002/term.2566},
	author = {Malahias, Michael-Alexander and Nikolaou, Vasileios S and Johnson, Elizabeth O and Kaseta, Maria-Kyriaki and Kazas, Sotirios-Tsambikos and Babis, George C}
}
