<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nikolaou, Vassilios S</style></author><author><style face="normal" font="default" size="100%">Harwood, Paul J</style></author><author><style face="normal" font="default" size="100%">Karadimas, Efthimios J</style></author><author><style face="normal" font="default" size="100%">Tan, Hiang Boon</style></author><author><style face="normal" font="default" size="100%">Giannoudis, Peter V</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel anticoagulants: new evidence for emerging drugs and their potential application in major lower limb surgery.</style></title><secondary-title><style face="normal" font="default" size="100%">Curr Vasc Pharmacol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Curr Vasc Pharmacol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticoagulants</style></keyword><keyword><style  face="normal" font="default" size="100%">Benzimidazoles</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical Trials as Topic</style></keyword><keyword><style  face="normal" font="default" size="100%">Dabigatran</style></keyword><keyword><style  face="normal" font="default" size="100%">Drugs, Investigational</style></keyword><keyword><style  face="normal" font="default" size="100%">Factor Xa Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Lower Extremity</style></keyword><keyword><style  face="normal" font="default" size="100%">Morpholines</style></keyword><keyword><style  face="normal" font="default" size="100%">Orthopedic Procedures</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyridines</style></keyword><keyword><style  face="normal" font="default" size="100%">Rivaroxaban</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiophenes</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombin</style></keyword><keyword><style  face="normal" font="default" size="100%">Venous Thromboembolism</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011 Jan</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">54-60</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">For decades, parenteral drugs, such as the low molecular weight heparins and unfractionated heparins or vitamin K antagonists, have been used as anticoagulants for prevention of venous thromboembolism following major lower limb surgery. However, these regiments have limitations that rendered the quest for new anticoagulants mandatory. Recently, research has been focused on the development of orally active small molecules that directly target thrombin or activated factor X (FXa). These regiments exhibit a number of characteristics that an &quot;ideal&quot; anticoagulant should possess. Currently, two agents, dabigatran etexilate and rivaroxaban, which inhibit thrombin and FXa, respectively have been approved in the European Union and Canada for venous thromboprophylaxis in patients undergoing elective hip- or knee-replacement surgery. Other agents are at an early or late stage of clinical evaluation. In this study, we summarize the current evidence for these new developed or under development drugs regarding their applications in the filed of lower limb orthopaedic surgery.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21044021?dopt=Abstract</style></custom1></record></records></xml>