<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kokras, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Pastromas, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Porto, Tatiany H</style></author><author><style face="normal" font="default" size="100%">Kafetzopoulos, Vasilios</style></author><author><style face="normal" font="default" size="100%">Mavridis, Theodore</style></author><author><style face="normal" font="default" size="100%">Dalla, Christina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute but not sustained aromatase inhibition displays antidepressant properties.</style></title><secondary-title><style face="normal" font="default" size="100%">Int J Neuropsychopharmacol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Int. J. Neuropsychopharmacol.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidepressive Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Aromatase inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Administration Schedule</style></keyword><keyword><style  face="normal" font="default" size="100%">Estradiol</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluoxetine</style></keyword><keyword><style  face="normal" font="default" size="100%">Immobility Response, Tonic</style></keyword><keyword><style  face="normal" font="default" size="100%">Letrozole</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitriles</style></keyword><keyword><style  face="normal" font="default" size="100%">progesterone</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword><keyword><style  face="normal" font="default" size="100%">Triazoles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2014 Aug</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">1307-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Aromatase inhibitors block the conversion of androgens to oestrogens and are used for the treatment of hormone-responsive breast cancer in menopause and recently also in premenopausal women. We investigate whether decreased oestrogen synthesis following aromatase inhibition leads to a depressive-like behavioural response in cycling female rats. Using the forced swim test (FST) we estimate the response of acute (three injections in 24 h) and sustained (7 d) letrozole and fluoxetine administration. Acute aromatase inhibition decreases immobility duration in the FST, indicating its antidepressant potential. Instead, sustained aromatase inhibition did not show such antidepressant potential. Testosterone elevation associates with the decreased depressive behaviour in the FST following acute letrozole treatment, but interestingly progesterone explains the increased swimming behaviour. Present findings may have potential implications for women treated with aromatase inhibitors, especially before menopause, as well as for the role of gonadal hormones in the expression of depressive symptoms and antidepressant response. </style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/24674846?dopt=Abstract</style></custom1></record></records></xml>