@article {16603,
	title = {Coronary and peripheral blood flow changes following biventricular pacing and their relation to heart failure improvement},
	journal = {Europace.},
	volume = {8},
	year = {2006},
	note = {DA - 20060421
IS - 1099-5129 (Print)
IS - 1099-5129 (Linking)
LA - eng
PT - Journal Article
RN - 0 (Biomarkers)
RN - 0 (Vascular Cell Adhesion Molecule-1)
RN - 114471-18-0 (Natriuretic Peptide, Brain)
RN - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB - IM},
	month = {2006/01//},
	pages = {44 - 50},
	abstract = {AIMS: To study the effect of cardiac resynchronization therapy (CRT) on coronary and peripheral arterial circulation and to assess whether their changes are related to the improvement in patients{\textquoteright} functional capacity and prognostically important biochemical markers. METHODS AND RESULTS: Twenty-five patients were studied (New York Heart Association classes III and IV, left ventricular ejection fraction <35\%, QRS>120 ms, mean age 66 +/- 2.1 years). Coronary blood flow (CBF), forearm blood flow (FBF), and their reserve were measured by transoesophageal echocardiography (in cm/s) and venous occlusion plethysmography (in mL/100 mL/min) at baseline and following 3 months of CRT. N-terminal-pro-brain natriuretic peptide (Nt-pro-BNP) and serum adhesion molecules, sICAM-1 and sVCAM-1 levels were also assessed. CRT induced a non-significant increase in resting CBF (baseline vs. CRT: 52.1 +/- 5.5 vs. 58.2 +/- 3.6, P: NS), whereas hyperaemic CBF was increased by CRT (baseline vs. CRT: 67.8 +/- 6.8 vs. 79.8 +/- 6.2, P < 0.05). Significant increases were observed in resting FBF (baseline vs. CRT: 1.6 +/- 0.2 vs. 2.6 +/- 0.2, P < 0.05) and hyperaemic FBF (baseline vs. CRT: 2.1 +/- 0.2 vs. 3.2 +/- 0.3, P < 0.05). The per cent difference in hyperaemic FBF was related to the per cent change in Nt-pro-BNP (r = -0.71, P < 0.05) and the per cent improvement in exercise duration (r = 0.80, P < 0.05). CONCLUSION: CRT induces favourable changes in coronary and peripheral arterial function. Changes in peripheral blood flow are related to patients{\textquoteright} improvement and may be prognostically significant},
	keywords = {Aged, Analysis of Variance, Biomarkers, Blood, Blood Flow Velocity, blood supply, Cardiac Pacing,Artificial, Coronary Circulation, Echocardiography, Exercise Test, Female, Forearm, Greece, Heart failure, Humans, Intercellular Adhesion Molecule-1, Linear Models, Male, Natriuretic Peptide,Brain, Oxygen consumption, physiopathology, Plethysmography, Prognosis, therapy, Treatment Outcome, Ultrasonography, Vascular Cell Adhesion Molecule-1},
	url = {PM:16627408},
	author = {Flevari,P. and Theodorakis, G and Paraskevaidis, I and Kolokathis,F. and Kostopoulou, A and Leftheriotis, D and Kroupis, C. and Livanis, E and Kremastinos, D.T.}
}
