@article {16618,
	title = {Cell adhesion molecules in relation to simvastatin and hormone replacement therapy in coronary artery disease},
	journal = {Eur.Heart J.},
	volume = {21},
	year = {2000},
	note = {DA - 20001018
IS - 0195-668X (Print)
IS - 0195-668X (Linking)
LA - eng
PT - Clinical Trial
PT - Journal Article
PT - Randomized Controlled Trial
RN - 0 (Anticholesteremic Agents)
RN - 0 (Cell Adhesion Molecules)
RN - 0 (Cholesterol, LDL)
RN - 0 (Estrogens, Conjugated (USP))
RN - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN - AGG2FN16EV (Simvastatin)
RN - C2QI4IOI2G (Medroxyprogesterone Acetate)
SB - IM},
	month = {2000/06//},
	pages = {975 - 980},
	abstract = {AIMS: To assess the effect of simvastatin, hormone replacement therapy and their combination on soluble cell adhesion molecules and plasma lipids, in hypercholesterolaemic post-menopausal women with coronary artery disease. METHODS: We studied 16 post-menopausal women with coronary artery disease and hypercholesterolaemia (total cholesterol >200mg x dl(-1) and LDL cholesterol >130 mg x dl(-1)). We compared simvastatin (20 mg daily) with hormone replacement therapy (0.625 mg conjugated oestrogen and 2.5 mg medroxyprogesterone acetate daily) and their combination, in a randomized, crossover, placebo controlled study. Each treatment period was 8 weeks long with a 4 week washout interval between treatments. Circulating cell adhesion molecules and plasma lipids were evaluated at the end of each treatment period. RESULTS: All three active treatments--simvastatin, hormone replacement therapy and the combination therapy--significantly reduced total and LDL cholesterol, compared to placebo (P<0.001). Only hormone replacement therapy, alone and in combination with simvastatin, significantly decreased lipoprotein(a) when compared to placebo (P<0.05), whereas simvastatin had no significant effect. Likewise, hormone replacement therapy and the combination therapy significantly reduced the intercellular adhesion molecule (ICAM-1) plasma levels (P=0.03 and P=0.02, respectively), while simvastatin, which was superior to hormone replacement therapy in lowering total and LDL cholesterol, did not modify ICAM-1 levels; the combination therapy was not more effective than hormone replacement therapy alone in ICAM-1 reduction. Neither the effect, on any treatment when compared to placebo, of VCAM-1 nor E-selectin levels differed significantly. CONCLUSIONS: Hormone replacement therapy may limit the inflammatory response to injury by modulating the expression of cell adhesion molecules from the endothelial cells, possibly in association with lipoprotein (a) reduction},
	keywords = {Aged, Anticholesteremic Agents, Blood, Cell adhesion molecules, Cholesterol,LDL, Complications, Coronary Disease, Cross-Over Studies, Drug Therapy, Drug Therapy,Combination, Estrogens,Conjugated (USP), Female, Greece, Hormone Replacement Therapy, Humans, Hypercholesterolemia, Intercellular Adhesion Molecule-1, Male, Medroxyprogesterone Acetate, Middle Aged, Simvastatin, therapeutic use, therapy},
	url = {PM:10901509},
	author = {Sbarouni, E and Kroupis, C. and Kyriakides, ZS and Koniavitou,K. and Kremastinos, D.T.}
}
