@article {16631,
	title = {Copeptin levels in patients with vasovagal syncope},
	journal = {Int.J.Cardiol.},
	volume = {230},
	year = {2017},
	note = {IS - 1874-1754 (Electronic)
IS - 0167-5273 (Linking)
LA - eng
PT - Journal Article
RN - 0 (Biomarkers)
RN - 0 (Glycopeptides)
RN - 0 (Protein Precursors)
RN - 0 (copeptins)
SB - IM},
	month = {2017/03/01/},
	pages = {642 - 645},
	abstract = {BACKGROUND AND PURPOSE: Vasovagal syncope (VVS) is linked to more than one pathophysiologic mechanisms. Copeptin, an emerging cardiovascular marker, is a surrogate for arginine-vasopressin, which increases following VVS. We aimed to assess the dynamic pattern of copeptin levels in typical VVS, categorized by the degree of vasoconstriction during orthostasis, and healthy controls. METHODS: The following groups were studied: Group A (n=21), with adequate limb vasoconstriction during the first min. of tilt, assessed by limb plethysmography (at least 30\% flow reduction); Group B (n=15), showing impaired vasoconstriction during orthostasis (<10\% reduction); Group C (n=18), history of VVS and negative tilt test result; Group D (n=18), healthy controls. Copeptin plasma levels were assessed before and 5min following tilt test positivity or termination. RESULTS: Baseline copeptin values were similar in all groups (8.3+/-6.4 in Group A, 5.7+/-2.3pmol/l in B, 6.0+/-1.9 in C, and 6.9+/-2.6 in D, p: 0.41). Significant increases in copeptin during tilt were observed in all Groups of VVS patients (A, B, C), including those with negative tilt (Group C: from 6.0+/-1.9 to 27.7+/-12.6pmol/l, p: 0.001), but not in controls. Following tilt termination, a greater increase was observed in copeptin values in Group B vs all other Groups A, C, and D (111.6+/-63.5 vs 29.5+/-51.3, 27.7+/-12.6, and 8.3+/-2.9, respectively). CONCLUSIONS: Copeptin increases following tilt not only in VVS with a positive response, but also in typical history patients with a negative test. Increased copeptin levels following orthostasis may be useful for diagnosing VVS},
	keywords = {Biomarkers, Blood, Diagnosis, Electrocardiography, Female, Follow-Up Studies, Glycopeptides, Greece, Heart Rate, Humans, Male, Middle Aged, physiology, physiopathology, Plethysmography, Protein Precursors, Retrospective Studies, Syncope,Vasovagal, Tilt-Table Test, Vasoconstriction},
	url = {PM:28073658},
	author = {Flevari,P. and Leftheriotis, D and Kroupis, C. and Antonakos, G. and Lekakis, J. and Dima, K.}
}
