@article {37954,
	title = {Vitamin B12 and Folate as Risk Factors for Retinal Vein Occlusion: A Meta-Analysis},
	journal = {Klin.Monbl.Augenheilkd.},
	volume = {239},
	year = {2022},
	note = {IS - 1439-3999 (Electronic)
IS - 0023-2165 (Linking)
LA - eng
PT - Journal Article
PT - Meta-Analysis
RN - 935E97BOY8 (Folic Acid)
RN - P6YC3EG204 (Vitamin B 12)
SB - IM},
	month = {2022/05//},
	pages = {709 - 716},
	abstract = {PURPOSE: To evaluate the association between serum vitamin B12/folate and retinal vein occlusion (RVO). METHODS: A comprehensive search of the PubMed database was performed, which identified 271 abstracts to be screened. Ten studies met our inclusion criteria and a meta-analysis of these comparative case-control studies was performed on the mean +/- standard deviation serum vitamin B12 and folate levels, without language restrictions. Nine studies with 720 patients with RVO and 613 controls were included in the meta-analysis for vitamin B12, and 10 studies with 784 patients with RVO and 677 controls in the meta-analysis for folate. RESULTS: There was no statistically significant difference between patients with RVO and controls in serum vitamin B12 levels (mean difference: - 40.25 pg/mL, p = 0.28), either central RVO (mean difference: - 18.24 pg/mL, p = 0.71) or branch RVO (mean difference: - 23.56 pg/mL, p = 0.48). On the contrary, the plasma folate level was significantly lower in RVO patients than in controls (mean difference: - 1.34 ng/mL, p = 0.001), as well as in patients with CRVO compared to controls (mean difference: - 1.48 ng/mL, p = 0.006), but not in BRVO patients (mean difference: - 0.72 ng/mL, p = 0.11). CONCLUSIONS: RVO is associated with low serum folate levels, but not with serum vitamin B12 levels},
	keywords = {Case-Control Studies, Diagnosis, Epidemiology, Folic Acid, Humans, Retinal Vein Occlusion, Risk Factors, Vitamin B 12},
	url = {PM:34000749},
	author = {Kazantzis,D. and Theodossiadis, P and Kroupis, C. and Theodossiadis, G and Chatziralli, I}
}
