@article {34248,
	title = {GemC1 is a critical switch for neural stem cell generation in the postnatal brain},
	journal = {Glia},
	volume = {67},
	year = {2019},
	pages = {2360-2373},
	publisher = {John Wiley \& Sons, Inc. Hoboken, USA},
	abstract = {The subventricular zone (SVZ) is one of two main niches where neurogenesis persists during adulthood, as it retains neural stem cells (NSCs) with self-renewal capacity and multi-lineage potency. Another critical cellular component of the niche is the population of postmitotic multiciliated ependymal cells. Both cell types are derived from radial glial cells that become specified to each lineage during embryogenesis. We show here that GemC1, encoding Geminin coiled-coil domain-containing protein 1, is associated with congenital hydrocephalus in humans and mice. Our results show that GemC1 deficiency drives cells toward a NSC phenotype, at the expense of multiciliated ependymal cell generation. The increased number of NSCs is accompanied by increased levels of proliferation and neurogenesis in the postnatal SVZ. Finally, GemC1-knockout cells display altered chromatin organization at multiple loci, further supporting a NSC identity. Together, these findings suggest that GemC1 regulates the balance between NSC generation and ependymal cell differentiation, with implications for the pathogenesis of human congenital hydrocephalus.},
	isbn = {0894-1491},
	url = {https://pubmed.ncbi.nlm.nih.gov/31328313/},
	author = {Lalioti, Maria-Eleni and Kaplani, Konstantina and Lokka, Georgia and Georgomanolis, Theodore and Kyrousi, Christina and Dong, Weilai and Dunbar, Ashley and Parlapani, Evangelia and Damianidou, Eleni and Spassky, Nathalie and Kahle, T Kristopfer and Papantonis, Argyris and Lygerou, Zoi and Taraviras, Stavros}
}
