@article {34261,
	title = {Non{\textendash}cell-autonomous regulation of interneuron specification mediated by extracellular vesicles},
	journal = {Science Advances},
	volume = {9},
	year = {2023},
	pages = {eadd8164},
	publisher = {American Association for the Advancement of Science},
	abstract = {Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in the extracellular matrix gene <em>LGALS3BP</em>, we show that extracellular vesicles released into the extracellular environment regulate the molecular differentiation of neurons, resulting in alterations in migratory dynamics. To investigate how extracellular vesicles affect neuronal specification and migration dynamics, we collected extracellular vesicles from ventral cerebral organoids carrying a mutation in <em>LGALS3BP</em>, previously identified in individuals with cortical malformations and neuropsychiatric disorders. These results revealed differences in protein composition and changes in dorsoventral patterning. Proteins associated with cell fate decision, neuronal migration, and extracellular matrix composition were altered in mutant extracellular vesicles. Moreover, we show that treatment with extracellular vesicles changes the transcriptomic profile in neural progenitor cells. Our results indicate that neuronal molecular differentiation can be influenced by extracellular vesicles.},
	isbn = {2375-2548},
	url = {https://pubmed.ncbi.nlm.nih.gov/37205765/},
	author = {Pipicelli, Fabrizia and Baumann, Natalia and Di Giaimo, Rossella and Forero-Echeverry, Andrea and Kyrousi, Christina and Bonrath, Rebecca and Maccarrone, Giuseppina and Jabaudon, Denis and Cappello, Silvia}
}
