@article {Krontira2024,
	title = {Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression},
	journal = {Neuron},
	volume = {112},
	year = {2024},
	month = {5},
	pages = {1426-1443.e11},
	publisher = {Neuron},
	abstract = {Glucocorticoids are important for proper organ maturation, and their levels are tightly regulated during development. Here, we use human cerebral organoids and mice to study the cell-type-specific effects of glucocorticoids on neurogenesis. We show that glucocorticoids increase a specific type of basal progenitors (co-expressing PAX6 and EOMES) that has been shown to contribute to cortical expansion in gyrified species. This effect is mediated via the transcription factor ZBTB16 and leads to increased production of neurons. A phenome-wide Mendelian randomization analysis of an enhancer variant that moderates glucocorticoid-induced ZBTB16 levels reveals causal relationships with higher educational attainment and altered brain structure. The relationship with postnatal cognition is also supported by data from a prospective pregnancy cohort study. This work provides a cellular and molecular pathway for the effects of glucocorticoids on human neurogenesis that relates to lasting postnatal phenotypes.},
	keywords = {Animals, Anthi C Krontira, Cerebral Cortex* / cytology, Cerebral Cortex* / drug effects, Cerebral Cortex* / metabolism, Cristiana Cruceanu, Developmental / drug effects, doi:10.1016/j.neuron.2024.02.005, Elisabeth B Binder, Extramural, Female, Gene Expression Regulation, Glucocorticoids* / pharmacology, Humans, Male, MEDLINE, Mice, N.I.H., National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, NCBI, Neural Stem Cells / drug effects, Neural Stem Cells / metabolism, Neurogenesis* / drug effects, Neurogenesis* / physiology, Neurons / drug effects, Neurons / metabolism, NIH, NLM, Non-U.S. Gov{\textquoteright}t, Organoids / drug effects, Organoids / metabolism, pmid:38442714, Pregnancy, Promyelocytic Leukemia Zinc Finger Protein* / metabolism, PubMed Abstract, Research Support},
	issn = {1097-4199},
	doi = {10.1016/J.NEURON.2024.02.005},
	url = {https://pubmed.ncbi.nlm.nih.gov/38442714/},
	author = {Krontira, Anthi C and Cruceanu, Cristiana and Dony, Leander and Kyrousi, Christina and Marie Helen Link and Nils Rek and P{\"o}hlchen, Dorothee and Catarina Raimundo and Signe Penner-Goeke and Alicia Schowe and Czamara, Darina and Marius Lahti-Pulkkinen and Sara Sammallahti and Elina Wolford and Kati Heinonen and Roeh, Simone and Sportelli, Vincenza and W{\"o}lfel, Barbara and Maik K{\"o}del and Susann Sauer and Monika Rex-Haffner and R{\"a}ikk{\"o}nen, Katri and Marta Labeur and Cappello, Silvia and Elisabeth B. Binder}
}
