@article {16356,
	title = {Craniofacial shape differs in patients with tooth agenesis: geometric morphometric analysis.},
	journal = {Eur J Orthod},
	volume = {39},
	year = {2017},
	month = {2017 Aug 01},
	pages = {345-351},
	abstract = {Aim : To evaluate the shape of the craniofacial complex in patients with tooth agenesis and compare it to matched controls.

Subjects and methods : The sample comprised 456 patients that were allocated to three groups: the agenesis group of 100 patients with at least one missing tooth, excluding third molars, the third molar agenesis group (3dMAG; one to four missing third molars) of 52 patients and the control group (CG) of 304 patients with no missing teeth. The main craniofacial structures depicted on lateral cephalograms were digitized and traced with 15 curves and 127 landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the whole craniofacial complex. For statistical analysis, permutation tests were used (10 000 permutations without replacement).

Results : Approximately half of the sample{\textquoteright}s variability was described by the first three principal components. Comparisons within the whole sample revealed sexual dimorphism of the craniofacial complex and its structures (P < 0.01). Differences between the agenesis group and matched controls were found in the shape of all craniofacial structures except for the cranial base (P < 0.05). Specifically, patients with agenesis presented with Class III tendency and hypodivergent skeletal pattern. However, the comparison between the 3dMAG and matched CG revealed no differences.

Conclusion : The shape of the craniofacial complex differs in patients with tooth agenesis suggesting that common factors are implicated in tooth development and craniofacial morphology.},
	keywords = {Abnormalities, Multiple, Adolescent, Adult, Anatomic Landmarks, Anodontia, Case-Control Studies, Cephalometry, Craniofacial Abnormalities, Female, Humans, Male, Mandible, Maxilla, Molar, Third, principal component analysis, Radiography, Skull Base, Young Adult},
	issn = {1460-2210},
	doi = {10.1093/ejo/cjw049},
	author = {Cocos, Alina and Halazonetis, Demetrios J}
}
