@article {37927,
	title = {Transporter Specificity: A Tale of Loosened Elevator-Sliding.},
	journal = {Trends Biochem Sci},
	volume = {46},
	year = {2021},
	month = {2021 Sep},
	pages = {708-717},
	abstract = {Elevator-type transporters are a group of proteins translocating nutrients and metabolites across cell membranes. Despite structural and functional differences, elevator-type transporters use a common mechanism of substrate translocation via reversible movements of a mobile core domain (the elevator), which includes the substrate binding site, along a rigid scaffold domain, stably anchored in the plasma membrane. How substrate specificity is determined in elevator transporters remains elusive. Here, I discuss how a recent report on the sliding elevator mechanism, seen under the context of genetic analysis of a prototype fungal transporter, sheds light on how specificity might be genetically modified. I propose that flexible specificity alterations might occur by {\textquoteright}loosening{\textquoteright} of the sliding mechanism from tight coupling to substrate binding.},
	keywords = {Aspergillus nidulans, Biological Transport, Fungal Proteins, Membrane Transport Proteins, Substrate Specificity},
	issn = {0968-0004},
	doi = {10.1016/j.tibs.2021.03.007},
	author = {Diallinas, George}
}
