@article {6610,
	title = {Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.},
	journal = {Genome Biol},
	volume = {18},
	year = {2017},
	month = {2017 Feb 14},
	pages = {28},
	abstract = {BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus.

RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli.

CONCLUSIONS: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.},
	issn = {1474-760X},
	doi = {10.1186/s13059-017-1151-0},
	author = {de Vries, Ronald P and Riley, Robert and Wiebenga, Ad and Aguilar-Osorio, Guillermo and Amillis, Sotiris and Uchima, Cristiane Akemi and Anderluh, Gregor and Asadollahi, Mojtaba and Askin, Marion and Barry, Kerrie and Battaglia, Evy and Bayram, {\"O}zg{\"u}r and Benocci, Tiziano and Braus-Stromeyer, Susanna A and Caldana, Camila and C{\'a}novas, David and Cerqueira, Gustavo C and Chen, Fusheng and Chen, Wanping and Choi, Cindy and Clum, Alicia and Dos Santos, Renato Augusto Corr{\^e}a and Dam{\'a}sio, Andr{\'e} Ricardo de Lima and Diallinas, George and Emri, Tam{\'a}s and Fekete, Erzs{\'e}bet and Flipphi, Michel and Freyberg, Susanne and Gallo, Antonia and Gournas, Christos and Habgood, Rob and Hainaut, Matthieu and Harispe, Mar{\'\i}a Laura and Henrissat, Bernard and Hild{\'e}n, Kristiina S and Hope, Ryan and Hossain, Abeer and Karabika, Eugenia and Karaffa, Levente and Kar{\'a}nyi, Zsolt and Kra{\v s}evec, Nada and Kuo, Alan and Kusch, Harald and LaButti, Kurt and Lagendijk, Ellen L and Lapidus, Alla and Levasseur, Anthony and Lindquist, Erika and Lipzen, Anna and Logrieco, Antonio F and MacCabe, Andrew and M{\"a}kel{\"a}, Miia R and Malavazi, Iran and Melin, Petter and Meyer, Vera and Mielnichuk, Natalia and Miskei, M{\'a}rton and Moln{\'a}r, {\'A}kos P and Mul{\'e}, Giuseppina and Ngan, Chew Yee and Orejas, Margarita and Orosz, Erzs{\'e}bet and Ouedraogo, Jean Paul and Overkamp, Karin M and Park, Hee-Soo and Perrone, Giancarlo and Piumi, Francois and Punt, Peter J and Ram, Arthur F J and Ram{\'o}n, Ana and Rauscher, Stefan and Record, Eric and Ria{\~n}o-Pach{\'o}n, Diego Mauricio and Robert, Vincent and R{\"o}hrig, Julian and Ruller, Roberto and Salamov, Asaf and Salih, Nadhira S and Samson, Rob A and S{\'a}ndor, Erzs{\'e}bet and Sanguinetti, Manuel and Sch{\"u}tze, Tabea and Sep{\v c}i{\'c}, Kristina and Shelest, Ekaterina and Sherlock, Gavin and Sophianopoulou, Vicky and Squina, Fabio M and Sun, Hui and Susca, Antonia and Todd, Richard B and Tsang, Adrian and Unkles, Shiela E and van de Wiele, Nathalie and van Rossen-Uffink, Diana and Oliveira, Juliana Velasco de Castro and Vesth, Tammi C and Visser, Jaap and Yu, Jae-Hyuk and Zhou, Miaomiao and Andersen, Mikael R and Archer, David B and Baker, Scott E and Benoit, Isabelle and Brakhage, Axel A and Braus, Gerhard H and Fischer, Reinhard and Frisvad, Jens C and Goldman, Gustavo H and Houbraken, Jos and Oakley, Berl and P{\'o}csi, Istv{\'a}n and Claudio Scazzocchio and Seiboth, Bernhard and vanKuyk, Patricia A and Wortman, Jennifer and Dyer, Paul S and Grigoriev, Igor V}
}
