<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">de Vries, Ronald P</style></author><author><style face="normal" font="default" size="100%">Riley, Robert</style></author><author><style face="normal" font="default" size="100%">Wiebenga, Ad</style></author><author><style face="normal" font="default" size="100%">Aguilar-Osorio, Guillermo</style></author><author><style face="normal" font="default" size="100%">Amillis, Sotiris</style></author><author><style face="normal" font="default" size="100%">Uchima, Cristiane Akemi</style></author><author><style face="normal" font="default" size="100%">Anderluh, Gregor</style></author><author><style face="normal" font="default" size="100%">Asadollahi, Mojtaba</style></author><author><style face="normal" font="default" size="100%">Askin, Marion</style></author><author><style face="normal" font="default" size="100%">Barry, Kerrie</style></author><author><style face="normal" font="default" size="100%">Battaglia, Evy</style></author><author><style face="normal" font="default" size="100%">Bayram, Özgür</style></author><author><style face="normal" font="default" size="100%">Benocci, Tiziano</style></author><author><style face="normal" font="default" size="100%">Braus-Stromeyer, Susanna A</style></author><author><style face="normal" font="default" size="100%">Caldana, Camila</style></author><author><style face="normal" font="default" size="100%">Cánovas, David</style></author><author><style face="normal" font="default" size="100%">Cerqueira, Gustavo C</style></author><author><style face="normal" font="default" size="100%">Chen, Fusheng</style></author><author><style face="normal" font="default" size="100%">Chen, Wanping</style></author><author><style face="normal" font="default" size="100%">Choi, Cindy</style></author><author><style face="normal" font="default" size="100%">Clum, Alicia</style></author><author><style face="normal" font="default" size="100%">Dos Santos, Renato Augusto Corrêa</style></author><author><style face="normal" font="default" size="100%">Damásio, André Ricardo de Lima</style></author><author><style face="normal" font="default" size="100%">Diallinas, George</style></author><author><style face="normal" font="default" size="100%">Emri, Tamás</style></author><author><style face="normal" font="default" size="100%">Fekete, Erzsébet</style></author><author><style face="normal" font="default" size="100%">Flipphi, Michel</style></author><author><style face="normal" font="default" size="100%">Freyberg, Susanne</style></author><author><style face="normal" font="default" size="100%">Gallo, Antonia</style></author><author><style face="normal" font="default" size="100%">Gournas, Christos</style></author><author><style face="normal" font="default" size="100%">Habgood, Rob</style></author><author><style face="normal" font="default" size="100%">Hainaut, Matthieu</style></author><author><style face="normal" font="default" size="100%">Harispe, María Laura</style></author><author><style face="normal" font="default" size="100%">Henrissat, Bernard</style></author><author><style face="normal" font="default" size="100%">Hildén, Kristiina S</style></author><author><style face="normal" font="default" size="100%">Hope, Ryan</style></author><author><style face="normal" font="default" size="100%">Hossain, Abeer</style></author><author><style face="normal" font="default" size="100%">Karabika, Eugenia</style></author><author><style face="normal" font="default" size="100%">Karaffa, Levente</style></author><author><style face="normal" font="default" size="100%">Karányi, Zsolt</style></author><author><style face="normal" font="default" size="100%">Kraševec, Nada</style></author><author><style face="normal" font="default" size="100%">Kuo, Alan</style></author><author><style face="normal" font="default" size="100%">Kusch, Harald</style></author><author><style face="normal" font="default" size="100%">LaButti, Kurt</style></author><author><style face="normal" font="default" size="100%">Lagendijk, Ellen L</style></author><author><style face="normal" font="default" size="100%">Lapidus, Alla</style></author><author><style face="normal" font="default" size="100%">Levasseur, Anthony</style></author><author><style face="normal" font="default" size="100%">Lindquist, Erika</style></author><author><style face="normal" font="default" size="100%">Lipzen, Anna</style></author><author><style face="normal" font="default" size="100%">Logrieco, Antonio F</style></author><author><style face="normal" font="default" size="100%">MacCabe, Andrew</style></author><author><style face="normal" font="default" size="100%">Mäkelä, Miia R</style></author><author><style face="normal" font="default" size="100%">Malavazi, Iran</style></author><author><style face="normal" font="default" size="100%">Melin, Petter</style></author><author><style face="normal" font="default" size="100%">Meyer, Vera</style></author><author><style face="normal" font="default" size="100%">Mielnichuk, Natalia</style></author><author><style face="normal" font="default" size="100%">Miskei, Márton</style></author><author><style face="normal" font="default" size="100%">Molnár, Ákos P</style></author><author><style face="normal" font="default" size="100%">Mulé, Giuseppina</style></author><author><style face="normal" font="default" size="100%">Ngan, Chew Yee</style></author><author><style face="normal" font="default" size="100%">Orejas, Margarita</style></author><author><style face="normal" font="default" size="100%">Orosz, Erzsébet</style></author><author><style face="normal" font="default" size="100%">Ouedraogo, Jean Paul</style></author><author><style face="normal" font="default" size="100%">Overkamp, Karin M</style></author><author><style face="normal" font="default" size="100%">Park, Hee-Soo</style></author><author><style face="normal" font="default" size="100%">Perrone, Giancarlo</style></author><author><style face="normal" font="default" size="100%">Piumi, Francois</style></author><author><style face="normal" font="default" size="100%">Punt, Peter J</style></author><author><style face="normal" font="default" size="100%">Ram, Arthur F J</style></author><author><style face="normal" font="default" size="100%">Ramón, Ana</style></author><author><style face="normal" font="default" size="100%">Rauscher, Stefan</style></author><author><style face="normal" font="default" size="100%">Record, Eric</style></author><author><style face="normal" font="default" size="100%">Riaño-Pachón, Diego Mauricio</style></author><author><style face="normal" font="default" size="100%">Robert, Vincent</style></author><author><style face="normal" font="default" size="100%">Röhrig, Julian</style></author><author><style face="normal" font="default" size="100%">Ruller, Roberto</style></author><author><style face="normal" font="default" size="100%">Salamov, Asaf</style></author><author><style face="normal" font="default" size="100%">Salih, Nadhira S</style></author><author><style face="normal" font="default" size="100%">Samson, Rob A</style></author><author><style face="normal" font="default" size="100%">Sándor, Erzsébet</style></author><author><style face="normal" font="default" size="100%">Sanguinetti, Manuel</style></author><author><style face="normal" font="default" size="100%">Schütze, Tabea</style></author><author><style face="normal" font="default" size="100%">Sepčić, Kristina</style></author><author><style face="normal" font="default" size="100%">Shelest, Ekaterina</style></author><author><style face="normal" font="default" size="100%">Sherlock, Gavin</style></author><author><style face="normal" font="default" size="100%">Sophianopoulou, Vicky</style></author><author><style face="normal" font="default" size="100%">Squina, Fabio M</style></author><author><style face="normal" font="default" size="100%">Sun, Hui</style></author><author><style face="normal" font="default" size="100%">Susca, Antonia</style></author><author><style face="normal" font="default" size="100%">Todd, Richard B</style></author><author><style face="normal" font="default" size="100%">Tsang, Adrian</style></author><author><style face="normal" font="default" size="100%">Unkles, Shiela E</style></author><author><style face="normal" font="default" size="100%">van de Wiele, Nathalie</style></author><author><style face="normal" font="default" size="100%">van Rossen-Uffink, Diana</style></author><author><style face="normal" font="default" size="100%">Oliveira, Juliana Velasco de Castro</style></author><author><style face="normal" font="default" size="100%">Vesth, Tammi C</style></author><author><style face="normal" font="default" size="100%">Visser, Jaap</style></author><author><style face="normal" font="default" size="100%">Yu, Jae-Hyuk</style></author><author><style face="normal" font="default" size="100%">Zhou, Miaomiao</style></author><author><style face="normal" font="default" size="100%">Andersen, Mikael R</style></author><author><style face="normal" font="default" size="100%">Archer, David B</style></author><author><style face="normal" font="default" size="100%">Baker, Scott E</style></author><author><style face="normal" font="default" size="100%">Benoit, Isabelle</style></author><author><style face="normal" font="default" size="100%">Brakhage, Axel A</style></author><author><style face="normal" font="default" size="100%">Braus, Gerhard H</style></author><author><style face="normal" font="default" size="100%">Fischer, Reinhard</style></author><author><style face="normal" font="default" size="100%">Frisvad, Jens C</style></author><author><style face="normal" font="default" size="100%">Goldman, Gustavo H</style></author><author><style face="normal" font="default" size="100%">Houbraken, Jos</style></author><author><style face="normal" font="default" size="100%">Oakley, Berl</style></author><author><style face="normal" font="default" size="100%">Pócsi, István</style></author><author><style face="normal" font="default" size="100%">Claudio Scazzocchio</style></author><author><style face="normal" font="default" size="100%">Seiboth, Bernhard</style></author><author><style face="normal" font="default" size="100%">vanKuyk, Patricia A</style></author><author><style face="normal" font="default" size="100%">Wortman, Jennifer</style></author><author><style face="normal" font="default" size="100%">Dyer, Paul S</style></author><author><style face="normal" font="default" size="100%">Grigoriev, Igor V</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.</style></title><secondary-title><style face="normal" font="default" size="100%">Genome Biol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Genome Biol.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Feb 14</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">28</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus.

RESULTS: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli.

CONCLUSIONS: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28196534?dopt=Abstract</style></custom1></record></records></xml>