@article {10829,
	title = {Transmission Dynamics of HIV-1 Drug Resistance among Treatment-Na{\"\i}ve Individuals in Greece: The Added Value of Molecular Epidemiology to Public Health.},
	journal = {Genes (Basel)},
	volume = {8},
	year = {2017},
	month = {2017 11 13},
	abstract = {The presence of human immunodeficiency virus type 1 (HIV-1) drug resistance among drug-na{\"\i}ve patients remains stable, although the proportion of patients with virological failure to therapy is decreasing. The dynamics of transmitted resistance among drug-na{\"\i}ve patients remains largely unknown. The prevalence of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was 16.9\% among treatment-na{\"\i}ve individuals in Greece. We aimed to investigate the transmission dynamics and the effective reproductive number () of the locally transmitted NNRTI resistance. We analyzed sequences with dominant NNRTI resistance mutations (E138A and K103N) found within monophyletic clusters (local transmission networks (LTNs)) from patients in Greece. For the K103N LTN, thewas >1 between 2008 and the first half of 2013. For all E138A LTNs, thewas >1 between 1998 and 2015, except the most recent one (E138A_4), where thewas >1 between 2006 and 2011 and approximately equal to 1 thereafter. K103N and E138A_4 showed similar characteristics with a more recent origin, higherduring the first years of the sub-epidemics, and a declining trend in the number of transmissions during the last two years. In the remaining LTNs the epidemic was still expanding. Our study highlights the added value of molecular epidemiology to public health.},
	issn = {2073-4425},
	doi = {10.3390/genes8110322},
	author = {Paraskevis, Dimitrios and Kostaki, Evangelia and Gargalianos, Panagiotis and Xylomenos, Georgios and Lazanas, Marios and Chini, Maria and Skoutelis, Athanasios and Papastamopoulos, Vasileios and Paraskeva, Dimitra and Antoniadou, Anastasia and Papadopoulos, Antonios and Psichogiou, Mina and Daikos, Georgios L and Chrysos, Georgios and Paparizos, Vasileios and Kourkounti, Sofia and Sambatakou, Helen and Sipsas, Nikolaos V and Lada, Malvina and Panagopoulos, Periklis and Maltezos, Efstratios and Drimis, Stylianos and Hatzakis, Angelos}
}
