@article {10876,
	title = {High prevalence of the UGT1A1*28 variant in HIV-infected individuals in Greece.},
	journal = {Int J STD AIDS},
	volume = {25},
	year = {2014},
	month = {2014 Oct},
	pages = {860-5},
	abstract = {Hyperbilirubinaemia with or without jaundice is one of the side effects of atazanavir boosted with low-dose ritonavir (ATV/rit) related to the drug plasma levels, as a result of its metabolism by UGT1A1 - uridine diphosphate-glucuronosyl transferase. Genotyping for UGT1A1*28 before initiation of antiretroviral therapy containing atazanavir may aid in identifying individuals at risk of hyperbilirubinaemia. Our objective was to estimate the prevalence of the UGTA1A1*28 polymorphism in HIV-infected individuals in Greece and to determine its potential association with hyperbilirubinaemia in patients receiving ATV/rit. The prevalence of the UGTA1A1*28 variant was estimated in 79 HIV-infected patients prior to the administration of the first-line treatment. The UGTA1A1*28 variant was detected in 46 out of 79 individuals (58.2\%). Antiretroviral therapy was administered to 64/79 patients (81\%). Among them, 26/64 (40.6\%) received ATV/rit. Of the ATV/rit-treated patients, 14 were found to be carriers of the UGT1A1*28 variant (54\%), and maximum serum bilirubin levels were significantly higher in the carrier population (4.71 vs. 2.69 mg/dL, p = 0.026). In 50\% of the population, maximum levels were recorded in the first month of follow-up. Although carriage of UGT1A1 is linked with the development of hyperbilirubinaemia, the implementation of a pharmacogenomic approach in clinical practice cannot yet be recommended as a standard of care.},
	keywords = {Adult, Aged, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Atazanavir Sulfate, Bilirubin, Cross-Sectional Studies, Glucuronosyltransferase, Greece, HIV Infections, HIV Protease Inhibitors, Humans, Hyperbilirubinemia, Middle Aged, Oligopeptides, Pharmacogenetics, Polymorphism, Genetic, Prevalence, Pyridines, Ritonavir},
	issn = {1758-1052},
	doi = {10.1177/0956462414523259},
	author = {Panagopoulos, P and Paraskevis, D and Katsarolis, I and Sypsa, V and Detsika, M and Protopapas, K and Antoniadou, A and Papadopoulos, A. and Petrikkos, G and Hatzakis, A}
}
