@article {20348,
	title = {Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs},
	journal = {VirusesVirusesViruses},
	volume = {12},
	number = {8},
	year = {2020},
	note = {1999-4915Kirichenko, AlinaOrcid: 0000-0002-7116-0138Lapovok, IlyaOrcid: 0000-0002-6328-1415Baryshev, Pavelvan de Vijver, David A M Cvan Kampen, Jeroen J ABoucher, Charles A BParaskevis, DimitriosOrcid: 0000-0001-6167-7152Kireev, DmitryJournal ArticleResearch Support, Non-U.S. Gov{\textquoteright}tViruses. 2020 Jul 31;12(8):838. doi: 10.3390/v12080838.},
	month = {Jul 31},
	edition = {2020/08/06},
	abstract = {The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). In this study, we have described the prevalence of INSTI DR in a Russian cohort and the genetic features of HIV-1 integrase sub-subtype A6. We included 408 HIV infected patients who were not exposed to INSTI. Drug resistance mutations (DRMs) were detected among 1.3\% of ART-na{\"\i}ve patients and among 2.7\% of INSTI-na{\"\i}ve patients. The prevalence of 12 polymorphic mutations was significantly different between sub-subtypes A6 and A1. Analysis of the genetic barriers determined two positions in which subtype A (A1 and A6) showed a higher genetic barrier (G140C and V151I) compared with subtype B, and one position in which subtypes A1 and B displayed a higher genetic barrier (L74M and L74I) than sub-subtype A6. Additionally, we confirmed that the L74I mutation was selected at the early stage of the epidemic and subsequently spread as a founder effect in Russia. Our data have added to the overall understanding of the genetic features of sub-subtype A6 in the context of drug resistance.},
	keywords = {*A6, *founder effect, *genetic barrier, *Hiv-1, *Insti, *integrase, *L74i, *Phylogenetics, *polymorphisms, *Russia, in the collection, analyses, or interpretation of data, in the writing, of the manuscript, or in the decision to publish the results., of the study},
	isbn = {1999-4915},
	author = {Kirichenko, A. and Lapovok, I. and Baryshev, P. and van de Vijver, D A M C and van Kampen, J. J. A. and Boucher, C A B and Paraskevis, D and Kireev, D.}
}
