@article {20351,
	title = {Near Full-length Genomic Sequencing and Molecular Analysis of HIV-Infected Individuals in a Network-based Intervention (TRIP) in Athens, Greece: Evidence that Transmissions Occur More Frequently from those with High HIV-RNA},
	journal = {Curr HIV ResCurr HIV ResCurr HIV Res},
	volume = {16},
	number = {5},
	year = {2018},
	note = {1873-4251Kostaki, Evangelia-GeorgiaFrampton, DanielParaskevis, DimitriosPantavou, KaterinaFerns, BridgetRaffle, JadeGrant, PaulKozlakidis, ZisisHadjikou, AndriaPavlitina, EiriniWilliams, Leslie DHatzakis, AngelosFriedman, Samuel RNastouli, EleniNikolopoulos, Georgios KDP1 DA034989/DA/NIDA NIH HHS/United StatesP30 DA011041/DA/NIDA NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tCurr HIV Res. 2018;16(5):345-353. doi: 10.2174/1570162X17666190130120757.},
	pages = {345-353},
	edition = {2019/02/02},
	abstract = {BACKGROUND: TRIP (Transmission Reduction Intervention Project) was a network-based, contact tracing approach to locate and link to care, mostly people who inject drugs (PWID) with recent HIV infection. OBJECTIVE: We investigated whether sequences from HIV-infected participants with high viral load cluster together more frequently than what is expected by chance. METHODS: Paired end reads were generated for 104 samples using Illumina MiSeq next-generation sequencing. RESULTS: 63 sequences belonged to previously identified local transmission networks of PWID (LTNs) of an HIV outbreak in Athens, Greece. For two HIV-RNA cut-offs (105 and 106 IU/mL), HIV transmissions were more likely between PWID with similar levels of HIV-RNA (p<0.001). 10 of the 14 sequences (71.4\%) from PWID with HIV-RNA >106 IU/mL were clustered in 5 pairs. For 4 of these clusters (80\%), there was in each one of them at least one sequence from a recently HIVinfected PWID. CONCLUSION: We showed that transmissions are more likely among PWID with high viremia.},
	keywords = {*Disease Transmission, Infectious, *Hiv, *HIV transmission, *Hiv-rna, *Pwid, *recent infection., *Trip, *Viral Load, Adult, Cluster analysis, Contact Tracing, Female, Genotype, Greece/epidemiology, High-Throughput Nucleotide Sequencing, HIV Infections/*epidemiology/*transmission/virology, Humans, Male, molecular epidemiology, RNA, Viral/*blood/genetics, Substance Abuse, Intravenous/complications},
	isbn = {1570-162X (Print)1570-162x},
	author = {Kostaki, E. G. and Frampton, D. and Paraskevis, D and Pantavou, K. and Ferns, B. and Raffle, J. and Grant, P. and Kozlakidis, Z. and Hadjikou, A. and Pavlitina, E. and Williams, L. D. and Hatzakis, A and Friedman, S. R. and Nastouli, E. and Nikolopoulos, G K}
}
