@article {20354,
	title = {Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach},
	journal = {ElifeElifeElife},
	volume = {7},
	year = {2018},
	note = {2050-084xKostaki, Evangelia-GeorgiaOrcid: 0000-0002-3346-0930Karamitros, TimokratisOrcid: 0000-0003-0841-9159Stefanou, GaryfalliaMamais, IoannisAngelis, KonstantinosHatzakis, AngelosKramvis, AnnaParaskevis, DimitriosOrcid: 0000-0001-6167-7152Journal ArticleResearch Support, Non-U.S. Gov{\textquoteright}tElife. 2018 Aug 7;7:e36709. doi: 10.7554/eLife.36709.},
	month = {Aug 7},
	edition = {2018/08/08},
	abstract = {Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by the reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype.},
	keywords = {*global dispersal, *hepatitis B virus, *infectious disease, *microbiology, *Molecular Epidemiology, *phylogeny, *phylogeography, *virus, Africa South of the Sahara, DNA, Viral/genetics, Europe, Genome, Viral/*genetics, Genotype, Hepatitis B virus/*genetics/pathogenicity, Hepatitis B/epidemiology/*genetics/virology, Humans, Phylogeny, Phylogeography, Sequence Analysis, DNA},
	isbn = {2050-084x},
	author = {Kostaki, E. G. and Karamitros, T. and Stefanou, G. and Mamais, I. and Angelis, K. and Hatzakis, A and Kramvis, A. and Paraskevis, D}
}
