@article {20380,
	title = {Phylodynamics Helps to Evaluate the Impact of an HIV Prevention Intervention},
	journal = {VirusesVirusesViruses},
	volume = {12},
	number = {4},
	year = {2020},
	note = {1999-4915Vasylyeva, Tetyana IZarebski, AlexanderSmyrnov, PavloWilliams, Leslie DKorobchuk, AniaLiulchuk, MariiaZadorozhna, ViktoriiaNikolopoulos, GeorgiosParaskevis, DimitriosSchneider, JohnSkaathun, BrittPybus, Oliver GFriedman, Samuel RDP1 DA034989/DA/NIDA NIH HHS/United StatesP30 AI036214/NH/NIH HHS/United StatesR01AI136056/NH/NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tViruses. 2020 Apr 20;12(4):469. doi: 10.3390/v12040469.},
	month = {Apr 20},
	edition = {2020/04/25},
	abstract = {Assessment of the long-term population-level effects of HIV interventions is an ongoing public health challenge. Following the implementation of a Transmission Reduction Intervention Project (TRIP) in Odessa, Ukraine, in 2013-2016, we obtained HIV pol gene sequences and used phylogenetics to identify HIV transmission clusters. We further applied the birth-death skyline model to the sequences from Odessa (n = 275) and Kyiv (n = 92) in order to estimate changes in the epidemic{\textquoteright}s effective reproductive number (R(e)) and rate of becoming uninfectious (δ). We identified 12 transmission clusters in Odessa; phylogenetic clustering was correlated with younger age and higher average viral load at the time of sampling. Estimated R(e) were similar in Odessa and Kyiv before the initiation of TRIP; R(e) started to decline in 2013 and is now below R(e) = 1 in Odessa (R(e) = 0.4, 95\%HPD 0.06-0.75), but not in Kyiv (R(e) = 2.3, 95\%HPD 0.2-5.4). Similarly, estimates of δ increased in Odessa after the initiation of TRIP. Given that both cities shared the same HIV prevention programs in 2013-2019, apart from TRIP, the observed changes in transmission parameters are likely attributable to the TRIP intervention. We propose that molecular epidemiology analysis can be used as a post-intervention effectiveness assessment tool.},
	keywords = {*birth-death model, *Hiv, *intervention, *phylodynamics, *prevention},
	isbn = {1999-4915},
	author = {Vasylyeva, T. I. and Zarebski, A. and Smyrnov, P. and Williams, L. D. and Korobchuk, A. and Liulchuk, M. and Zadorozhna, V. and Nikolopoulos, G. and Paraskevis, D and Schneider, J. and Skaathun, B. and Pybus, O. G. and Friedman, S. R.}
}
