<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abecasis, Ana B</style></author><author><style face="normal" font="default" size="100%">Wensing, Annemarie M J</style></author><author><style face="normal" font="default" size="100%">Paraskevis, Dimitris</style></author><author><style face="normal" font="default" size="100%">Vercauteren, Jurgen</style></author><author><style face="normal" font="default" size="100%">Theys, Kristof</style></author><author><style face="normal" font="default" size="100%">Van de Vijver, David A M C</style></author><author><style face="normal" font="default" size="100%">Albert, Jan</style></author><author><style face="normal" font="default" size="100%">Asjö, Birgitta</style></author><author><style face="normal" font="default" size="100%">Balotta, Claudia</style></author><author><style face="normal" font="default" size="100%">Beshkov, Danail</style></author><author><style face="normal" font="default" size="100%">Camacho, Ricardo J</style></author><author><style face="normal" font="default" size="100%">Clotet, Bonaventura</style></author><author><style face="normal" font="default" size="100%">De Gascun, Cillian</style></author><author><style face="normal" font="default" size="100%">Griskevicius, Algis</style></author><author><style face="normal" font="default" size="100%">Grossman, Zehava</style></author><author><style face="normal" font="default" size="100%">Hamouda, Osamah</style></author><author><style face="normal" font="default" size="100%">Horban, Andrzej</style></author><author><style face="normal" font="default" size="100%">Kolupajeva, Tatjana</style></author><author><style face="normal" font="default" size="100%">Korn, Klaus</style></author><author><style face="normal" font="default" size="100%">Kostrikis, Leon G</style></author><author><style face="normal" font="default" size="100%">Kücherer, Claudia</style></author><author><style face="normal" font="default" size="100%">Liitsola, Kirsi</style></author><author><style face="normal" font="default" size="100%">Linka, Marek</style></author><author><style face="normal" font="default" size="100%">Nielsen, Claus</style></author><author><style face="normal" font="default" size="100%">Otelea, Dan</style></author><author><style face="normal" font="default" size="100%">Paredes, Roger</style></author><author><style face="normal" font="default" size="100%">Poljak, Mario</style></author><author><style face="normal" font="default" size="100%">Puchhammer-Stöckl, Elisabeth</style></author><author><style face="normal" font="default" size="100%">Schmit, Jean-Claude</style></author><author><style face="normal" font="default" size="100%">Sönnerborg, Anders</style></author><author><style face="normal" font="default" size="100%">Stanekova, Danika</style></author><author><style face="normal" font="default" size="100%">Stanojevic, Maja</style></author><author><style face="normal" font="default" size="100%">Struck, Daniel</style></author><author><style face="normal" font="default" size="100%">Boucher, Charles A B</style></author><author><style face="normal" font="default" size="100%">Vandamme, Anne-Mieke</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics.</style></title><secondary-title><style face="normal" font="default" size="100%">Retrovirology</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Retrovirology</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bayes Theorem</style></keyword><keyword><style  face="normal" font="default" size="100%">Epidemics</style></keyword><keyword><style  face="normal" font="default" size="100%">Europe</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk-Taking</style></keyword><keyword><style  face="normal" font="default" size="100%">Social Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Socioeconomic Factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2013 Jan 14</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.

RESULTS: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM &gt; IDUs &gt; heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots.

CONCLUSIONS: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients.</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/23317093?dopt=Abstract</style></custom1></record></records></xml>