<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kostaki, E. G.</style></author><author><style face="normal" font="default" size="100%">Frampton, D.</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Pantavou, K.</style></author><author><style face="normal" font="default" size="100%">Ferns, B.</style></author><author><style face="normal" font="default" size="100%">Raffle, J.</style></author><author><style face="normal" font="default" size="100%">Grant, P.</style></author><author><style face="normal" font="default" size="100%">Kozlakidis, Z.</style></author><author><style face="normal" font="default" size="100%">Hadjikou, A.</style></author><author><style face="normal" font="default" size="100%">Pavlitina, E.</style></author><author><style face="normal" font="default" size="100%">Williams, L. D.</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author><author><style face="normal" font="default" size="100%">Friedman, S. R.</style></author><author><style face="normal" font="default" size="100%">Nastouli, E.</style></author><author><style face="normal" font="default" size="100%">Nikolopoulos, G K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Near Full-length Genomic Sequencing and Molecular Analysis of HIV-Infected Individuals in a Network-based Intervention (TRIP) in Athens, Greece: Evidence that Transmissions Occur More Frequently from those with High HIV-RNA</style></title><secondary-title><style face="normal" font="default" size="100%">Curr HIV ResCurr HIV ResCurr HIV Res</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Current HIV research</style></alt-title><short-title><style face="normal" font="default" size="100%">Current HIV researchCurrent HIV research</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Disease Transmission, Infectious</style></keyword><keyword><style  face="normal" font="default" size="100%">*Hiv</style></keyword><keyword><style  face="normal" font="default" size="100%">*HIV transmission</style></keyword><keyword><style  face="normal" font="default" size="100%">*Hiv-rna</style></keyword><keyword><style  face="normal" font="default" size="100%">*Pwid</style></keyword><keyword><style  face="normal" font="default" size="100%">*recent infection.</style></keyword><keyword><style  face="normal" font="default" size="100%">*Trip</style></keyword><keyword><style  face="normal" font="default" size="100%">*Viral Load</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Cluster analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Contact Tracing</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Throughput Nucleotide Sequencing</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections/*epidemiology/*transmission/virology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Viral/*blood/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance Abuse, Intravenous/complications</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><number><style face="normal" font="default" size="100%">5</style></number><edition><style face="normal" font="default" size="100%">2019/02/02</style></edition><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">345-353</style></pages><isbn><style face="normal" font="default" size="100%">1570-162X (Print)1570-162x</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: TRIP (Transmission Reduction Intervention Project) was a network-based, contact tracing approach to locate and link to care, mostly people who inject drugs (PWID) with recent HIV infection. OBJECTIVE: We investigated whether sequences from HIV-infected participants with high viral load cluster together more frequently than what is expected by chance. METHODS: Paired end reads were generated for 104 samples using Illumina MiSeq next-generation sequencing. RESULTS: 63 sequences belonged to previously identified local transmission networks of PWID (LTNs) of an HIV outbreak in Athens, Greece. For two HIV-RNA cut-offs (105 and 106 IU/mL), HIV transmissions were more likely between PWID with similar levels of HIV-RNA (p&lt;0.001). 10 of the 14 sequences (71.4%) from PWID with HIV-RNA &gt;106 IU/mL were clustered in 5 pairs. For 4 of these clusters (80%), there was in each one of them at least one sequence from a recently HIVinfected PWID. CONCLUSION: We showed that transmissions are more likely among PWID with high viremia.</style></abstract><accession-num><style face="normal" font="default" size="100%">30706819</style></accession-num><notes><style face="normal" font="default" size="100%">1873-4251Kostaki, Evangelia-GeorgiaFrampton, DanielParaskevis, DimitriosPantavou, KaterinaFerns, BridgetRaffle, JadeGrant, PaulKozlakidis, ZisisHadjikou, AndriaPavlitina, EiriniWilliams, Leslie DHatzakis, AngelosFriedman, Samuel RNastouli, EleniNikolopoulos, Georgios KDP1 DA034989/DA/NIDA NIH HHS/United StatesP30 DA011041/DA/NIDA NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tCurr HIV Res. 2018;16(5):345-353. doi: 10.2174/1570162X17666190130120757.</style></notes><custom2><style face="normal" font="default" size="100%">PMC6446520</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Department of Infection and Immunity, UCL, London, United Kingdom.Medical School, University of Cyprus, Nicosia, Cyprus.NIHR Biomedical Research Centre, UCLH/UCL, London, United Kingdom.Department of Clinical Virology, UCLH, London, United Kingdom.Division of Infection and Immunity, Faculty of Medical Sciences, UCL and Farr Institute of Health Informatics Research, London, United Kingdom.European University Cyprus, Nicosia, Cyprus.Transmission Reduction Intervention Project, Athens site, Athens, Greece.National Development and Research Institutes, New York, United States.Department of Population, Policy and Practice, UCL GOS Institute of Child Health, London, United Kingdom.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>