<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kostaki, E. G.</style></author><author><style face="normal" font="default" size="100%">Hodges-Mameletzis, I</style></author><author><style face="normal" font="default" size="100%">Magiorkinis, G</style></author><author><style face="normal" font="default" size="100%">Adamis, G.</style></author><author><style face="normal" font="default" size="100%">Xylomenos, G</style></author><author><style face="normal" font="default" size="100%">Nikolopoulos, G.</style></author><author><style face="normal" font="default" size="100%">Lazanas, M</style></author><author><style face="normal" font="default" size="100%">Chini, M</style></author><author><style face="normal" font="default" size="100%">Mangafas, N.</style></author><author><style face="normal" font="default" size="100%">Skoutelis, A</style></author><author><style face="normal" font="default" size="100%">Papastamopoulos, V</style></author><author><style face="normal" font="default" size="100%">Antoniadou, A</style></author><author><style face="normal" font="default" size="100%">Papadopoulos, A.</style></author><author><style face="normal" font="default" size="100%">Protopapas, K</style></author><author><style face="normal" font="default" size="100%">Psichogiou, M</style></author><author><style face="normal" font="default" size="100%">Basoulis, D.</style></author><author><style face="normal" font="default" size="100%">Chrysos, G</style></author><author><style face="normal" font="default" size="100%">Paraskeva, D.</style></author><author><style face="normal" font="default" size="100%">Paparizos, V</style></author><author><style face="normal" font="default" size="100%">Kourkounti, S</style></author><author><style face="normal" font="default" size="100%">Sambatakou, H</style></author><author><style face="normal" font="default" size="100%">Sipsas, N V</style></author><author><style face="normal" font="default" size="100%">Lada, M</style></author><author><style face="normal" font="default" size="100%">Panagopoulos, P</style></author><author><style face="normal" font="default" size="100%">Maltezos, E</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Earlier treatment initiation is associated with a decreased number of HIV-1 subtype A1 transmissions in Greece</style></title><secondary-title><style face="normal" font="default" size="100%">Sex Transm InfectSex Transm InfectSex Transm Infect</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Sexually transmitted infections</style></alt-title><short-title><style face="normal" font="default" size="100%">Sexually transmitted infectionsSexually transmitted infections</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HIV</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">prevention</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jun 19</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2020/06/21</style></edition><isbn><style face="normal" font="default" size="100%">1368-4973</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVES: Subtypes A1 and B are the most prevalent HIV-1 clades in Greece. Subtype A1 epidemic is highly monophyletic and corresponds to transmissions that occurred locally. Our aim in this molecular epidemiology analysis was to investigate the role of early treatment in preventing new HIV-1 transmissions. METHODS: Our analysis focused on 791 subtype A1 sequences from treatment-naïve individuals in Greece. Estimation of infection dates was performed by molecular clock calculations using Bayesian methods. We estimated the time interval between (1) the infection and sampling dates (linkage to care window), (2) the sampling dates and antiretroviral therapy (ART) initiation (treatment window), and (3) the infection dates and ART initiation (transmissibility window) for the study population. We also inferred the putative source of HIV infections between individuals of different groups divided according to the length of treatment, linkage to care or transmissibility window. RESULTS: A significant decline was detected for the treatment window during 2014-2015 versus the 2 previous years (p=0.0273), while the linkage to care interval remained unchanged during the study period. Inference of the putative source of HIV infections suggested that individuals with a recent diagnosis or narrow transmissibility window (time period between HIV infection and ART initiation) were not sources of HIV infections to other groups. Contrarily, a significant number of HIV infections originated from individuals with longer transmissibility window interval. CONCLUSIONS: Our findings showed that the treatment window is decreasing over time, presumably due to the updated treatment guidelines. Our study also demonstrates that people treated earlier after infection do not transmit at high rates, thus documenting the benefits of early ART initiation in preventing ongoing HIV-1 transmission.</style></abstract><accession-num><style face="normal" font="default" size="100%">32561553</style></accession-num><notes><style face="normal" font="default" size="100%">1472-3263Kostaki, Evangelia GeorgiaOrcid: 0000-0002-3346-0930Hodges-Mameletzis, IoannisMagiorkinis, GkikasAdamis, GeorgiosXylomenos, GeorgiosNikolopoulos, GeorgiosLazanas, MariosChini, MariaMangafas, NikosSkoutelis, AthanasiosPapastamopoulos, VasileiosAntoniadou, AnastasiaPapadopoulos, AntoniosProtopapas, KonstantinosPsichogiou, MinaBasoulis, DimitriosChrysos, GeorgiosParaskeva, DimitraPaparizos, VasileiosKourkounti, SofiaSambatakou, HelenSipsas, Nikolaos VLada, MalvinaPanagopoulos, PeriklisMaltezos, EfstratiosHatzakis, AngelosParaskevis, DimitriosOrcid: 0000-0001-6167-7152Journal ArticleEnglandSex Transm Infect. 2020 Jun 19:sextrans-2020-054509. doi: 10.1136/sextrans-2020-054509.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.HIV Department, World Health Organization, Geneva, Switzerland.1st Department of Internal Medicine, G Gennimatas GH, Athens, Greece.Medical School, University of Cyprus, Nicosia, Cyprus.3rd Department of Internal Medicine-Infectious Diseases Unit, Red Cross General Hospital, Athens, Greece.5th Department of Medicine and Infectious Diseases, Evaggelismos GH, Athens, Greece.4th Department of Medicine, Attikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece.1st Department of Medicine, Laikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Department of Internal Medicine, Tzaneio GH, Piraeus, Greece.HIV/AIDS Unit, A Syngros Hospital of Dermatology and Venereology, Athens, Greece.HIV Unit, 2nd Department of Internal Medicine, Hippokration GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Department of Pathophysiology, Laikon GH, Medical School, National and Kapodistrian University of Athens, Athens, Greece.2nd Department of Internal Medicine, Sismanogleion GH, Athens, Greece.Department of Internal Medicine, University GH, Democritus University of Thrace, Alexandroupolis, Greece.Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece dparask@med.uoa.gr.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>