<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kostrikis, L G</style></author><author><style face="normal" font="default" size="100%">Hezka, J</style></author><author><style face="normal" font="default" size="100%">Stylianou, D. C.</style></author><author><style face="normal" font="default" size="100%">E Kostaki</style></author><author><style face="normal" font="default" size="100%">Andreou, M.</style></author><author><style face="normal" font="default" size="100%">Kousiappa, I</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Demetriades, I</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HIV-1 transmission networks across Cyprus (2010-2012)</style></title><secondary-title><style face="normal" font="default" size="100%">PLoS OnePLoS OnePLoS One</style></secondary-title><alt-title><style face="normal" font="default" size="100%">PloS one</style></alt-title><short-title><style face="normal" font="default" size="100%">PloS onePloS one</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*HIV-1/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyprus/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Resistance, Viral/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Geography, Medical</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections/*transmission</style></keyword><keyword><style  face="normal" font="default" size="100%">Homosexuality, Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phylogeny</style></keyword><keyword><style  face="normal" font="default" size="100%">Prospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Young Adult</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><number><style face="normal" font="default" size="100%">4</style></number><edition><style face="normal" font="default" size="100%">2018/04/24</style></edition><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">e0195660</style></pages><isbn><style face="normal" font="default" size="100%">1932-6203</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">A molecular epidemiology study of HIV-1 infection was conducted in one hundred diagnosed and untreated HIV-1-infected patients in Cyprus between 2010 and 2012, representing 65.4% of all the reported HIV-1 infections in Cyprus in this three-year period, using a previously defined enrolment strategy. Eighty-two patients were newly diagnosed (genotypic drug resistance testing within six months from diagnosis), and eighteen patients were HIV-1 diagnosed for a longer period or the diagnosis date was unknown. Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 41.0 and 19.0% respectively, followed by subtype C (7.0%), F1 (8.0%), CRF02_AG (4.0%), A2 (2.0%), other circulating recombinant forms (CRFs) (7.0%) and unknown recombinant forms (URFs) (12%). Most of the newly-diagnosed study subjects were Cypriots (63%), males (78%) with median age 39 (Interquartile Range, IQR 33-48) reporting having sex with other men (MSM) (51%). A high rate of clustered transmission of subtype B drug-sensitive strains to reverse transcriptase and protease inhibitors was observed among MSM, twenty-eight out of forty-one MSM study subjects (68.0%) infected were implicated in five transmission clusters, two of which are sub-subtype A1 and three of which are subtype B strains. The two largest MSM subtype B clusters included nine and eight Cypriot men, respectively, living in all major cities in Cyprus. There were only three newly diagnosed patients with transmitted drug resistant HIV-1 strains, one study subject from the United Kingdom infected with subtype B strain and one from Romania with sub-subtype A2 strain, both with PI drug resistance mutation M46L and one from Greece with sub-subtype A1 with non-nucleoside reverse transcriptase inhibitors (NNRTI) drug resistance mutation K103N.</style></abstract><accession-num><style face="normal" font="default" size="100%">29684083</style></accession-num><notes><style face="normal" font="default" size="100%">1932-6203Kostrikis, Leondios GOrcid: 0000-0002-5340-7109Hezka, JohanaStylianou, Dora CKostaki, EvangeliaAndreou, MariaKousiappa, IoannaParaskevis, DimitriosDemetriades, IoannisJournal ArticlePLoS One. 2018 Apr 23;13(4):e0195660. doi: 10.1371/journal.pone.0195660. eCollection 2018.</style></notes><custom2><style face="normal" font="default" size="100%">PMC5912776</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Biological Sciences, University of Cyprus, Aglantzia, Nicosia, Cyprus.Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Goudi, Athens, Greece.AIDS Clinic, Larnaca General Hospital, Larnaca, Cyprus.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>