<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Stylianou, D. C.</style></author><author><style face="normal" font="default" size="100%">Hezka, J</style></author><author><style face="normal" font="default" size="100%">Stern, Z.</style></author><author><style face="normal" font="default" size="100%">Oikonomopoulou, M</style></author><author><style face="normal" font="default" size="100%">Mamais, I.</style></author><author><style face="normal" font="default" size="100%">Kostrikis, L G</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HCV Phylogeography of the General Population and High-Risk Groups in Cyprus Identifies the Island as a Global Sink for and Source of Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Sci RepSci RepSci Rep</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Scientific reports</style></alt-title><short-title><style face="normal" font="default" size="100%">Scientific reportsScientific reports</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cyprus/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepacivirus/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis C/transmission/*virology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Epidemiology/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Phylogeny</style></keyword><keyword><style  face="normal" font="default" size="100%">Phylogeography</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Viral/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Envelope Proteins/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Nonstructural Proteins/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul 11</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><edition><style face="normal" font="default" size="100%">2019/07/13</style></edition><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">10077</style></pages><isbn><style face="normal" font="default" size="100%">2045-2322</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Hepatitis C virus (HCV) genotype and subtype distribution differs according to geographic origin and transmission risk category. Previous molecular epidemiology studies suggest the presence of multiple subtypes among Cypriot subjects. To investigate HCV genotype- and subtype-specific dissemination patterns, origins, and transmission in Cyprus, we analyzed HCV sequences encoding partial Core-E1 and NS5B regions. Analyzed populations comprised the general population and high-risk cohorts in Cyprus and a globally sampled dataset. Maximum-likelihood phylogeny reconstruction with bootstrap evaluation, character reconstruction using parsimony, and bootstrap trees estimated by ML were performed to identify the geographic origin of HCV subtypes and statistically significant dispersal pathways among geographic regions. Phylogeographic analyses traced the origin of subtypes in the general population and among PWID in Cyprus to unique and overlapping globally distributed regions. Phylogenetic analysis in Core-E1 revealed that most sequences from incarcerated populations in Cyprus clustered with the general population and PWID. We estimate that HCV infections in Cyprus originate from multiple global sources while most HCV transmissions among incarcerated individuals occur locally. This analysis is one of a few studies tracing HCV dispersal patterns using global datasets, and these practices and findings should inform how HCV epidemics are targeted by future prevention policies.</style></abstract><accession-num><style face="normal" font="default" size="100%">31296903</style></accession-num><notes><style face="normal" font="default" size="100%">2045-2322Paraskevis, DimitriosOrcid: 0000-0001-6167-7152Stylianou, Dora CHezka, JohanaStern, ZachariahOikonomopoulou, MarthaMamais, IoannisCyprus PWID NetworkKostrikis, Leondios GOrcid: 0000-0002-5340-7109Journal ArticleResearch Support, Non-U.S. Gov'tSci Rep. 2019 Jul 11;9(1):10077. doi: 10.1038/s41598-019-46552-7.</style></notes><custom2><style face="normal" font="default" size="100%">PMC6624375</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece. lkostrik@ucy.ac.cy.</style></auth-address><remote-database-provider><style face="normal" font="default" size="100%">NLM</style></remote-database-provider></record></records></xml>