@article {5934,
	title = {sCD31/sPECAM-1 levels in breast milk and sera of mother-infant pairs in the early postpartum period},
	journal = {Early Human Development},
	volume = {67},
	year = {2002},
	month = {2002///},
	pages = {61 - 68},
	abstract = {Immunomediators seem to have a central role in the immune system of both human milk and newborn infants. CD31/PECAM-1 is an adhesion molecule, member of Ig gene superfamily, mediating cell-cell adhesion in both homophilic and heterophilic ways. Levels of the soluble form of PECAM-1 (sPECAM-1) were evaluated on the 2nd and 5th day postpartum in breast milk and serum paired samples from 20 lactating women as well as in time-matched serum from their single, term, healthy neonates. Concentrations of sPECAM-1 in breast milk (median, range) on both the 2nd (2.05 ng/ml, 0.0-7.2) and 5th day postpartum (0.89 ng/ml, 0.0-3.6) were about 10 and 20 times lower than those (mean {\textpm} SD) in controls (healthy adults) (19.83 {\textpm} 5.17, p < 7 {\texttimes} 10-8), showing a significant fall from the 2nd to the 5th day postpartum (p < 0.0005). Maternal serum sPECAM-1 values (mean {\textpm} SD) were significantly lower on the 2nd day postpartum (14.21 {\textpm} 5.15 ng/ml) than those in controls (p < 0.002), but reached control values on the 5th day postpartum after a significant rise (p < 0.0075). Neonatal serum sPECAM-1 values with no significant difference between the 2nd (14.4 {\textpm} 4.11 ng/ml) and 5th day of life (14.54 {\textpm} 4.99 ng/ml) were significantly lower than those in controls (p < 0.002). Values of sPECAM-1 in milk and sera of lactating mothers and their neonates on the 2nd day postpartum depended on the mode of delivery, being significantly lower after caesarean section (p < 0.034, p < 0.0075 and p < 0.035, respectively). In conclusion, our findings in the early postpartum period demonstrate that: (a) sPECAM-1 is present in human milk in low and decreasing concentrations; (b) the shedding of sPECAM-1 is an established component of the neonatal immune system from birth, though in lower concentrations than in adults, possibly reflecting its immaturity; and (c) the mode of delivery has a significant effect on sPECAM-1 values in milk and sera of lactating mothers and their neonates; the lower values after caesarean section may reveal a deranged endothelial homeostasis. {\textcopyright} 2002 Elsevier Science Ireland Ltd. All rights reserved.},
	keywords = {Adhesion molecules, Colostrum, Human milk, Lactating women, Mode of delivery, Term neonates},
	author = {Giannaki, G. and Rizos, D. and Xyni, K. and Sarandakou, A. and Phocas, I. and Creatsas, G.}
}
