@article {5940,
	title = {Sex hormones in postmenopausal women receiving low-dose hormone therapy: The effect of BMI},
	journal = {Obesity},
	volume = {19},
	year = {2011},
	month = {2011///},
	pages = {988 - 993},
	abstract = {The aim of our study was to evaluate the effect of BMI on the change in circulating sex hormone in postmenopausal women during 6 months of oral continuous combined low-dose hormone therapy (HT). Fifty postmenopausal women were allocated to receive daily one tablet containing combination of 17Β-estradiol (1mg)/norethindrone acetate (0.5mg) for 6 months. Serum levels of follicle-stimulating hormone (FSH), estradiol, total testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), free estrogen index (FEI), Δ4-androstendione (Δ4A), and dehydroepiandrosterone sulfate were assessed at baseline and at the end of 6 months. Mean absolute values and percent changes from baseline were compared between lean and overweight women. Mean FSH decreased and mean 17Β-estradiol increased significantly in both groups (FSH lean: 82.3 26.7 decreased to 45.0{\textpm}17.0mIU/ml, P = 0.0001; FSH overweight: 85.5{\textpm}22.1 decreased to 52.3{\textpm}23.8mIU/ml, P = 0.003; P between groups = 0.661; E2 lean: 23.24{\textpm}12.55 increased to 53.62{\textpm}28.29pg/ml, P = 0.006; E2 overweight: 24.17{\textpm}10.88 increased to 68.36{\textpm} 53.99pg/ml, P = 0.0001; P between groups = 0.619). Lean individuals had statistically significant higher increments of FAI and specifically FEI compared to overweight (FEI lean; 0.14{\textpm}0.09 increased to 0.29{\textpm}0.14, P = 0.009; overweight 0.23{\textpm}0.18 increased to 0.52{\textpm}0.40, P = 0.126; P between groups = 0.034). Although BMI does not affect total 17Β-estradiol changes, free sex steroid concentrations increase more steeply in lean compared to overweight women receiving oral low-dose HT. {\textcopyright} 2011 The Obesity Society.},
	author = {Lambrinoudaki, I. and Armeni, E. and Rizos, D. and Deligeoroglou, E. and Kofinakos, P. and Kaparos, G. and Alexandrou, A and Creatsa, M. and Logothetis, E. and Kouskouni, E.}
}
