@article {5965,
	title = {Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery},
	journal = {Journal of Investigative Surgery},
	volume = {28},
	year = {2015},
	month = {2015///},
	pages = {8 - 17},
	abstract = {Copyright {\textcopyright} 2015 Informa Healthcare USA, Inc. Purpose/Aim: To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery. Materials and Methods: This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve gastrectomy, with a mean follow-up of four years. Calcium metabolism indices and bone turnover markers were assessed according to the presence of secondary hyperparathyroidism and the Bsm1 vitamin D receptor genotypes. Results: Secondary hyperparathyroidism (42.2\% of sample) was associated with lower levels of 25hydroxyvitamin D and elevated markers of bone turnover. In subjects without secondary hyperparathyroidism, presence of the unfavorable B allele resulted in higher levels of parathormone (Bb and BB vs. bb genotype: 50.3 {\textpm} 8.2 pg/dl vs. 44.4 {\textpm} 10.7 pg/dl, p = .011, adjusted for weight loss, baseline body mass index, 25hydroxyvitamin D, surgical procedure, and duration after surgery). In the whole sample, patients bearing the unfavorable B allele exhibited lower weight loss, a parameter that was negatively associated with markers of bone resorption. Conclusions: Secondary hyperparathyroidism is highly prevalent after bariatric surgery. Bsm1 vitamin D receptor polymorphism may have an effect in early stages of calcium metabolism imbalance, while no association is detected in patients who have already developed secondary hyperparathyroidism. Moreover, vitamin D receptor polymorphism is associated with post-surgery weight loss, a process related to bone turnover.},
	keywords = {Bariatric Surgery, Bsm1 VDR polymorphism, Calcium metabolism, Parathormone, Roux-en-Y Gastric bypass, Sleeve gastrectomy},
	author = {Alexandrou, A and Armeni, E. and Kaparos, G. and Rizos, D. and Tsoka, E. and Deligeoroglou, E. and Creatsa, M. and Augoulea, A. and Diamantis, T and Lambrinoudaki, I.}
}
