@article {6034,
	title = {The incidence of 21α-hydroxylase deficiency in Greek hyperandrogenic women: Screening and diagnosis},
	journal = {Gynecological Endocrinology},
	volume = {12},
	year = {1998},
	month = {1998///},
	pages = {89 - 96},
	abstract = {The purpose of this prospective study was to determine the incidence of any form of 21α-hydroxylase deficiency among Greek women with hyperandrogenic symptoms, and to test the predictive value of basal serum 17-hydroxyprogesterone (17-OHP) in the early follicular phase as a screening index for patient preselection to adrenocorticotropic hormone (ACTH) testing. Eighty-eight unselected women with hyperandrogenic symptoms were examined in the Gynecological Endocrinology Unit of the Second Department of Obstetrics and Gynecology of Athens University. Using the ACTH-stimulated 17-OHP values at 60 minutes (17-OHP60) the study population was divided into four groups (A, B, C and D). Clinical and basal hormonal parameters as well as serum 17-OHP60 values and human leukocyte antigens were studied. Both clinical and basal hormonal parameters could be used to distinguish only patients with severe 21α-hydroxylase deficiency (group A). In contrast, patients with moderate non-classical congenital adrenal hyperplasia (NC-CAH; group B), heterozygotes for NC-CAH (group C), and unaffected females (group D) can be diagnosed and classified only by serum 17-OHP60 values. In conclusion, the incidence of NC-CAH in Greek females with hyperandrogenic symptoms is 3.4\%. The positive predictive value of basal 17-OHP is only 13\% for this disease. Only 17-OHP60 helps to diagnose and classify moderate and mild forms of NC-CAH. Thus, it seems that ACTH testing is imperative in every subject suspected of this enzymatic disorder.},
	keywords = {17-Hydroxyprogesterone, 21α-hydroxylase, HLA antigens, Hyperandrogenic women, NC-CAH, Screening},
	author = {Trakakis, E. and Chryssikopoulos, A. and Phocas, I. and Sarandakou, A. and Rizos, D. and Stavropoulos-Giokas, C.}
}
