<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alexandrou, A</style></author><author><style face="normal" font="default" size="100%">Armeni, E.</style></author><author><style face="normal" font="default" size="100%">Kaparos, G.</style></author><author><style face="normal" font="default" size="100%">Rizos, D.</style></author><author><style face="normal" font="default" size="100%">Tsoka, E.</style></author><author><style face="normal" font="default" size="100%">Deligeoroglou, E.</style></author><author><style face="normal" font="default" size="100%">Creatsa, M.</style></author><author><style face="normal" font="default" size="100%">Augoulea, A.</style></author><author><style face="normal" font="default" size="100%">Diamantis, T</style></author><author><style face="normal" font="default" size="100%">Lambrinoudaki, I.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Investigative Surgery</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bariatric Surgery</style></keyword><keyword><style  face="normal" font="default" size="100%">Bsm1 VDR polymorphism</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcium metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Parathormone</style></keyword><keyword><style  face="normal" font="default" size="100%">Roux-en-Y Gastric bypass</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleeve gastrectomy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2015///</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">28</style></volume><pages><style face="normal" font="default" size="100%">8 - 17</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Copyright © 2015 Informa Healthcare USA, Inc. Purpose/Aim: To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery. Materials and Methods: This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve gastrectomy, with a mean follow-up of four years. Calcium metabolism indices and bone turnover markers were assessed according to the presence of secondary hyperparathyroidism and the Bsm1 vitamin D receptor genotypes. Results: Secondary hyperparathyroidism (42.2% of sample) was associated with lower levels of 25hydroxyvitamin D and elevated markers of bone turnover. In subjects without secondary hyperparathyroidism, presence of the unfavorable B allele resulted in higher levels of parathormone (Bb and BB vs. bb genotype: 50.3 ± 8.2 pg/dl vs. 44.4 ± 10.7 pg/dl, p = .011, adjusted for weight loss, baseline body mass index, 25hydroxyvitamin D, surgical procedure, and duration after surgery). In the whole sample, patients bearing the unfavorable B allele exhibited lower weight loss, a parameter that was negatively associated with markers of bone resorption. Conclusions: Secondary hyperparathyroidism is highly prevalent after bariatric surgery. Bsm1 vitamin D receptor polymorphism may have an effect in early stages of calcium metabolism imbalance, while no association is detected in patients who have already developed secondary hyperparathyroidism. Moreover, vitamin D receptor polymorphism is associated with post-surgery weight loss, a process related to bone turnover.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue></record></records></xml>