<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lambrinoudaki, I.</style></author><author><style face="normal" font="default" size="100%">Kaparos, G.</style></author><author><style face="normal" font="default" size="100%">Rizos, D.</style></author><author><style face="normal" font="default" size="100%">Galapi, F.</style></author><author><style face="normal" font="default" size="100%">Alexandrou, A</style></author><author><style face="normal" font="default" size="100%">Sergentanis, T.N.</style></author><author><style face="normal" font="default" size="100%">Creatsa, M.</style></author><author><style face="normal" font="default" size="100%">Christodoulakos, G.</style></author><author><style face="normal" font="default" size="100%">Kouskouni, E.</style></author><author><style face="normal" font="default" size="100%">Botsis, D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Apolipoprotein e and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women</style></title><secondary-title><style face="normal" font="default" size="100%">Clinical Endocrinology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009///</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">71</style></volume><pages><style face="normal" font="default" size="100%">284 - 290</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Objective Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD). Design Cross-sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity. Patients In total 84 healthy postmenopausal women aged 49-69 years. Measurements FT3, FT4, anti-TPO and anti-TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2/E3/E4, paraoxonase 1 A/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G/5G, cholesterol 7-α hydroxylase A204C and cholesterol ester transfer protein B1/B2. Results A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (P = 0·0005) than women with the E3/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild-type genotype (P = 0·047). A statistically significant positive association (P = 0·049) was also observed between anti-TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene. Conclusions Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti-Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated. © 2009 Blackwell Publishing Ltd.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue></record></records></xml>