@article {26623,
	title = {Evidence by molecular profiling for a placental origin of infantile hemangioma},
	journal = {Proc Natl Acad Sci U S AProc Natl Acad Sci U S AProc Natl Acad Sci U S A},
	volume = {102},
	number = {52},
	year = {2005},
	note = {Barnes, Carmen MHuang, SuiKaipainen, ArjaSanoudou, DespinaChen, Emy JEichler, Gabriel SGuo, YuchunYu, YingIngber, Donald EMulliken, John BBeggs, Alan HFolkman, JudahFishman, Steven JengP01 NS40928/NS/NINDS NIH HHS/R01 AR044345/AR/NIAMS NIH HHS/R01 AR44345/AR/NIAMS NIH HHS/P01 CA045548/CA/NCI NIH HHS/P01 CA45548-18/CA/NCI NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tResearch Support, U.S. Gov{\textquoteright}t, Non-P.H.S.2005/12/21 09:00Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19097-102. doi: 10.1073/pnas.0509579102. Epub 2005 Dec 19.},
	month = {Dec 27},
	pages = {19097-102},
	abstract = {The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium.},
	keywords = {*Gene Expression Regulation, Neoplastic, 17-Hydroxysteroid Dehydrogenases/genetics, Cluster analysis, Databases, Genetic, Endothelium, Vascular/pathology, Gene Expression Regulation, Glycoproteins/genetics, Hemangioma/*genetics/metabolism/*pathology, Humans, Immunohistochemistry, Immunophenotyping, Lung Neoplasms/genetics/pathology, Placenta/metabolism/*pathology, RNA, Messenger/metabolism, RNA/metabolism, Tissue Distribution, Vascular Neoplasms/*genetics/metabolism/*pathology},
	isbn = {0027-8424 (Print)0027-8424 (Linking)},
	author = {Barnes, C. M. and Huang, S. and Kaipainen, A. and Sanoudou, D. and Chen, E. J. and Eichler, G. S. and Guo, Y. and Yu, Y. and Ingber, D. E. and Mulliken, J. B. and Beggs, A. H. and Folkman, J. and Fishman, S. J.}
}
