TY - JOUR T1 - Evidence by molecular profiling for a placental origin of infantile hemangioma JF - Proc Natl Acad Sci U S AProc Natl Acad Sci U S AProc Natl Acad Sci U S A Y1 - 2005 A1 - Barnes, C. M. A1 - Huang, S. A1 - Kaipainen, A. A1 - Sanoudou, D. A1 - Chen, E. J. A1 - Eichler, G. S. A1 - Guo, Y. A1 - Yu, Y. A1 - Ingber, D. E. A1 - Mulliken, J. B. A1 - Beggs, A. H. A1 - Folkman, J. A1 - Fishman, S. J. KW - *Gene Expression Regulation, Neoplastic KW - 17-Hydroxysteroid Dehydrogenases/genetics KW - Cluster analysis KW - Databases, Genetic KW - Endothelium, Vascular/pathology KW - Gene Expression Regulation KW - Glycoproteins/genetics KW - Hemangioma/*genetics/metabolism/*pathology KW - Humans KW - Immunohistochemistry KW - Immunophenotyping KW - Lung Neoplasms/genetics/pathology KW - Placenta/metabolism/*pathology KW - RNA, Messenger/metabolism KW - RNA/metabolism KW - Tissue Distribution KW - Vascular Neoplasms/*genetics/metabolism/*pathology AB - The origin of the pathogenic endothelial cells in common infantile hemangioma is unknown. We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570]. The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes. We found that the level of transcriptome similarity between placenta and hemangioma exceeded that of any other tissue compared and paralleled that observed between a given tissue and its derived tumor, such as normal and cancerous lung. The degree of similarity was even greater when a subset of endothelial cell-specific genes was analyzed. Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2. These data demonstrate the value of global molecular profiling of tissues as a tool for hypothesis-driven research. Furthermore, it suggests that the unique self-limited growth of infantile hemangioma may, in fact, mirror the lifetime of placental endothelium. VL - 102 SN - 0027-8424 (Print)0027-8424 (Linking) N1 - Barnes, Carmen MHuang, SuiKaipainen, ArjaSanoudou, DespinaChen, Emy JEichler, Gabriel SGuo, YuchunYu, YingIngber, Donald EMulliken, John BBeggs, Alan HFolkman, JudahFishman, Steven JengP01 NS40928/NS/NINDS NIH HHS/R01 AR044345/AR/NIAMS NIH HHS/R01 AR44345/AR/NIAMS NIH HHS/P01 CA045548/CA/NCI NIH HHS/P01 CA45548-18/CA/NCI NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.2005/12/21 09:00Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19097-102. doi: 10.1073/pnas.0509579102. Epub 2005 Dec 19. U2 - 1323205 JO - Proceedings of the National Academy of Sciences of the United States of AmericaProceedings of the National Academy of Sciences of the United States of America ER -