TY - JOUR T1 - Structural genomic abnormalities of chromosomes 9 and 18 in myxopapillary ependymomas JF - J Neuropathol Exp NeurolJ Neuropathol Exp NeurolJ Neuropathol Exp Neurol Y1 - 2003 A1 - Mahler-Araujo, M. B. A1 - Sanoudou, D. A1 - Tingby, O. A1 - Liu, L. A1 - Coleman, N. A1 - Ichimura, K. A1 - Collins, V. P. KW - Adolescent KW - Adult KW - Aged KW - Central Nervous System Neoplasms/genetics/pathology KW - Chromosomes, Human, Pair 18/chemistry/*genetics KW - Chromosomes, Human, Pair 9/chemistry/*genetics KW - Ependymoma/*genetics/pathology KW - Female KW - Humans KW - Male KW - Microsatellite Repeats/genetics KW - Middle Aged KW - Neoplasms, Neuroepithelial/*genetics/pathology KW - Peripheral Nervous System Neoplasms/genetics/pathology AB - Myxopapillary ependymomas (MPEs) are low-grade neuroepithelial tumors typically occurring in the conus-cauda equina-filum terminale region. Limited molecular and cytogenetic analysis of MPEs has not demonstrated consistent abnormalities. In an attempt to clarify the chromosomal status of these tumors and identify commonly aberrant regions in the genome we have combined 3 molecular/cyto/genetic methods to study 17 MPEs. Comparative genomic hybridization of 7/17 tumors identified concurrent gain on chromosomes 9 and 18 as the most frequent finding. The majority of the 17 tumors were also studied using microsatellite analysis with marker spanning the whole chromosomes 9 and 18 and interphase-FISH with centromeric probes for both chromosomes. Our combined results were consistent with concurrent gain in both chromosomes 9 and 18 in 11/17 cases, gain of either chromosome 9 or 18 and imbalance in the other chromosome in 3/17 tumors and allelic imbalances of chromosomes 9 or 18 in 3/17 and 1/17 tumors, respectively. Other abnormalities observed included gain of chromosomes 3, 4, 7, 8, 11, 13, 17q, 20, and X and loss of chromosomes 10 and 22. Our findings represent some steps towards understanding the molecular mechanisms involved in the development of MPE. VL - 62 SN - 0022-3069 (Print)0022-3069 (Linking) N1 - Mahler-Araujo, Maria BetaniaSanoudou, DespinaTingby, OlaLiu, LuColeman, NicholasIchimura, KoichiCollins, Vincent PeterengComparative StudyResearch Support, Non-U.S. Gov'tEngland2003/10/10 05:00J Neuropathol Exp Neurol. 2003 Sep;62(9):927-35. doi: 10.1093/jnen/62.9.927. JO - Journal of neuropathology and experimental neurologyJournal of neuropathology and experimental neurology ER -