<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abou-Saleh, H.</style></author><author><style face="normal" font="default" size="100%">Zouein, F. A.</style></author><author><style face="normal" font="default" size="100%">El-Yazbi, A.</style></author><author><style face="normal" font="default" size="100%">Sanoudou, D.</style></author><author><style face="normal" font="default" size="100%">Raynaud, C.</style></author><author><style face="normal" font="default" size="100%">Rao, C.</style></author><author><style face="normal" font="default" size="100%">Pintus, G.</style></author><author><style face="normal" font="default" size="100%">Dehaini, H.</style></author><author><style face="normal" font="default" size="100%">Eid, A. H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The march of pluripotent stem cells in cardiovascular regenerative medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Stem Cell Res TherStem Cell Res TherStem Cell Res Ther</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Stem cell research &amp; therapy</style></alt-title><short-title><style face="normal" font="default" size="100%">Stem cell research &amp; therapyStem cell research &amp; therapy</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiovascular Diseases/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Differentiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell- and Tissue-Based Therapy/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocytes, Cardiac/*metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Pluripotent Stem Cells/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Regenerative Medicine/*methods</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul 27</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">201</style></pages><isbn><style face="normal" font="default" size="100%">1757-6512 (Electronic)1757-6512 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a better understanding of molecular and cellular mechanisms of CVD as well as improved therapeutic strategies for the management or treatment of heart failure are increasingly needed. Loss of myocardium is a major driver of heart failure. An attractive approach that appears to provide promising results in reducing cardiac degeneration is stem cell therapy (SCT). In this review, we describe different types of stem cells, including embryonic and adult stem cells, and we provide a detailed discussion of the properties of induced pluripotent stem cells (iPSCs). We also present and critically discuss the key methods used for converting somatic cells to pluripotent cells and iPSCs to cardiomyocytes (CMs), along with their advantages and limitations. Integrating and non-integrating reprogramming methods as well as characterization of iPSCs and iPSC-derived CMs are discussed. Furthermore, we critically present various methods of differentiating iPSCs to CMs. The value of iPSC-CMs in regenerative medicine as well as myocardial disease modeling and cardiac regeneration are emphasized.</style></abstract><accession-num><style face="normal" font="default" size="100%">30053890</style></accession-num><notes><style face="normal" font="default" size="100%">Abou-Saleh, HaissamZouein, Fouad AEl-Yazbi, AhmedSanoudou, DespinaRaynaud, ChristopheRao, ChristopherPintus, GianfrancoDehaini, HassanEid, Ali HengResearch Support, Non-U.S. Gov'tReviewEngland2018/07/29 06:00Stem Cell Res Ther. 2018 Jul 27;9(1):201. doi: 10.1186/s13287-018-0947-5.</style></notes><custom2><style face="normal" font="default" size="100%">6062943</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar.Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.Department of Pharmacology and Toxicology, Alexandria University, Alexandria, Egypt.Clinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, &quot;Attikon&quot; Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.Sidra Medical and Research Center, Doha, Qatar.Department of Surgery, Queen Elizabeth Hospital, Woolwich, London, UK.Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.Department of Biological and Environmental Sciences, Qatar University, Doha, Qatar. ae81@aub.edu.lb.Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. ae81@aub.edu.lb.Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar. ae81@aub.edu.lb.</style></auth-address></record></records></xml>