<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vujasinovic, T.</style></author><author><style face="normal" font="default" size="100%">Zampera, A. S.</style></author><author><style face="normal" font="default" size="100%">Jackers, P.</style></author><author><style face="normal" font="default" size="100%">Sanoudou, D.</style></author><author><style face="normal" font="default" size="100%">Depaulis, A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico dynamic molecular interaction networks for the discovery of new therapeutic targets</style></title><secondary-title><style face="normal" font="default" size="100%">Curr Pharm DesCurr Pharm DesCurr Pharm Des</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Current pharmaceutical design</style></alt-title><short-title><style face="normal" font="default" size="100%">Current pharmaceutical designCurrent pharmaceutical design</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Models, Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain Diseases/*drug therapy/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Computational Biology/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">computer simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Therapy/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">gene expression profiling</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Targeted Therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacogenetics/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Genetic/drug effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Precision Medicine/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteomics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><number><style face="normal" font="default" size="100%">20</style></number><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">2241-51</style></pages><isbn><style face="normal" font="default" size="100%">1873-4286 (Electronic)1381-6128 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Systems biology has emerged as a major trend in biological research during the past decade. As living organisms are described in more and more detail, it aims at filling the gap between understanding basic molecular processes and complex biological systems in which new properties often emerge from the combination of these elementary processes. This approach culminates in the development of computer-based mathematical models of physiological and pathophysiological processes. We review the state of the art in dynamic modelling, with emphasis on two complementary approaches: the modelling of small systems that is mostly developed by academic teams and aims at understanding generic biological properties, and the modelling of large systems that is mostly implemented by industrial companies and aims at the generation of new therapeutic strategies. We also provide an example of such large-scale modelling applied to the identification of drug targets for neurodegeneration.</style></abstract><accession-num><style face="normal" font="default" size="100%">20459389</style></accession-num><notes><style face="normal" font="default" size="100%">Vujasinovic, TodorZampera, Andre SinisaJackers, PascaleSanoudou, DespinaDepaulis, AntoineengResearch Support, Non-U.S. Gov'tReviewUnited Arab Emirates2010/05/13 06:00Curr Pharm Des. 2010;16(20):2241-51. doi: 10.2174/138161210791792822.</style></notes><auth-address><style face="normal" font="default" size="100%">1Helios BioSciences, 8 avenue du General Sarrail 94010 Creteil Cedex France.</style></auth-address></record></records></xml>