<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arvanitis, DA</style></author><author><style face="normal" font="default" size="100%">Sanoudou, D.</style></author><author><style face="normal" font="default" size="100%">Kolokathis,F.</style></author><author><style face="normal" font="default" size="100%">Vafiadaki, E.</style></author><author><style face="normal" font="default" size="100%">Papalouka, V.</style></author><author><style face="normal" font="default" size="100%">Kontrogianni-Konstantopoulos, A.</style></author><author><style face="normal" font="default" size="100%">Theodorakis, GN</style></author><author><style face="normal" font="default" size="100%">Paraskevaidis,I.A.</style></author><author><style face="normal" font="default" size="100%">Adamopoulos, S</style></author><author><style face="normal" font="default" size="100%">Dorn, G. W., 2nd</style></author><author><style face="normal" font="default" size="100%">Kremastinos, D.T.</style></author><author><style face="normal" font="default" size="100%">Kranias, EG</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy</style></title><secondary-title><style face="normal" font="default" size="100%">Eur Heart JEur Heart JEur Heart J</style></secondary-title><alt-title><style face="normal" font="default" size="100%">European heart journal</style></alt-title><short-title><style face="normal" font="default" size="100%">European heart journalEuropean heart journal</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Arrhythmias, Cardiac/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcium-Binding Proteins/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiomyopathy, Dilated/*genetics/physiopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Death, Sudden, Cardiac/prevention &amp; control</style></keyword><keyword><style  face="normal" font="default" size="100%">Defibrillators, Implantable</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardial Contraction/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Genetic/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">20</style></number><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">2514-25</style></pages><isbn><style face="normal" font="default" size="100%">1522-9645 (Electronic)0195-668X (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">AIMS: To investigate whether genetic variants of the histidine-rich calcium (HRC)-binding protein are associated with idiopathic dilated cardiomyopathy (DCM) and its progression. METHODS AND RESULTS: We screened 123 idiopathic DCM patients and 96 healthy individuals by single-strand conformation polymorphism analysis and direct sequencing for genetic variants in HRC. Six polymorphisms were detected: Leu35Leu (A/G), Ser43Asn (G/A), Ser96Ala (T/G), Glu202_Glu203insGlu (-/GAG), Asp261del (GAT/-), and an in-frame insertion of 51 amino acids at His321. The analysis of their frequencies did not reveal any significant correlation with DCM development. However, the Ser96Ala polymorphism exhibited a statistically significant correlation with the occurrence of life-threatening ventricular arrhythmias. During a follow-up of 4.02 +/- 2.4 years, the risk for ventricular arrhythmias was higher (HR, 9.620; 95% CI, 2.183-42.394; P = 0.003) in the Ala/Ala patients, compared with Ser/Ser homozygous patients. On multivariable Cox regression analysis, the Ser96Ala polymorphism was the only significant genetic arrythmogenesis predictor in DCM patients (HR, 4.191; 95% CI, 0.838-20.967; P = 0.018). CONCLUSION: The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.</style></abstract><accession-num><style face="normal" font="default" size="100%">18617481</style></accession-num><notes><style face="normal" font="default" size="100%">Arvanitis, Demetrios ASanoudou, DespinaKolokathis, FotisVafiadaki, ElizabethPapalouka, VasilikiKontrogianni-Konstantopoulos, AikateriniTheodorakis, George NParaskevaidis, Ioannis AAdamopoulos, StamatiosDorn, Gerald W 2ndKremastinos, Dimitrios ThKranias, Evangelia GengHL26057/HL/NHLBI NIH HHS/HL64018/HL/NHLBI NIH HHS/HL77101/HL/NHLBI NIH HHS/Multicenter StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tEngland2008/07/12 09:00Eur Heart J. 2008 Oct;29(20):2514-25. doi: 10.1093/eurheartj/ehn328. Epub 2008 Jul 9.</style></notes><custom2><style face="normal" font="default" size="100%">2567024</style></custom2><auth-address><style face="normal" font="default" size="100%">Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece.</style></auth-address></record></records></xml>