<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kang, P. B.</style></author><author><style face="normal" font="default" size="100%">Kho, A. T.</style></author><author><style face="normal" font="default" size="100%">Sanoudou, D.</style></author><author><style face="normal" font="default" size="100%">Haslett, J. N.</style></author><author><style face="normal" font="default" size="100%">Dow, C. P.</style></author><author><style face="normal" font="default" size="100%">Han, M.</style></author><author><style face="normal" font="default" size="100%">Blasko, J. M.</style></author><author><style face="normal" font="default" size="100%">Lidov, H. G.</style></author><author><style face="normal" font="default" size="100%">Beggs, A. H.</style></author><author><style face="normal" font="default" size="100%">Kunkel, L. M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Variations in gene expression among different types of human skeletal muscle</style></title><secondary-title><style face="normal" font="default" size="100%">Muscle NerveMuscle NerveMuscle Nerve</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Muscle &amp; nerve</style></alt-title><short-title><style face="normal" font="default" size="100%">Muscle &amp; nerveMuscle &amp; nerve</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Gene Expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Aging/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Cadaver</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Discoidin Domain Receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">Electrophoresis</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle Fibers, Skeletal/cytology/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle, Skeletal/cytology/*physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor Protein-Tyrosine Kinases/genetics/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptors, Mitogen/genetics/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">spectrophotometry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">4</style></number><volume><style face="normal" font="default" size="100%">32</style></volume><pages><style face="normal" font="default" size="100%">483-91</style></pages><isbn><style face="normal" font="default" size="100%">0148-639X (Print)0148-639X (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">There is a consistent variation in the response of different skeletal muscle groups to mutations in genes known to cause muscular dystrophy, yet these muscles appear histologically similar. To better understand these phenotypic differences, we analyzed gene expression patterns in control muscle specimens obtained from four sites at autopsy: deltoid, quadriceps, gastrocnemius, and tibialis anterior (TA). A total of 35 muscle samples from nine individuals (four pediatric and five geriatric) were studied. Factors potentially influencing gene expression in the different samples included individuality, age, muscle type, gender, cause of death, postmortem interval, and ethnicity. The first three factors, in decreasing order, were found to have a significant impact on the stratification of muscle specimens. A novel analytic method, using a second round of normalization, was used to elicit differences between muscle types. This approach may be extended to a broader survey, potentially elucidating a molecular classification of the skeletal muscles.</style></abstract><accession-num><style face="normal" font="default" size="100%">15962335</style></accession-num><notes><style face="normal" font="default" size="100%">Kang, Peter BKho, Alvin TSanoudou, DespinaHaslett, Judith NDow, Chad PHan, MeiBlasko, Jessica MLidov, Hart G WBeggs, Alan HKunkel, Louis MengP50 NS040828/NS/NINDS NIH HHS/1 K08 NS048180/NS/NINDS NIH HHS/AR-44345/AR/NIAMS NIH HHS/NS-40828/NS/NINDS NIH HHS/Comparative StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.2005/06/18 09:00Muscle Nerve. 2005 Oct;32(4):483-91. doi: 10.1002/mus.20356.</style></notes><auth-address><style face="normal" font="default" size="100%">Genomics Program, Enders 561, Howard Hughes Medical Institute and Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.</style></auth-address></record></records></xml>