<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sanoudou, D.</style></author><author><style face="normal" font="default" size="100%">Tingby, O.</style></author><author><style face="normal" font="default" size="100%">Ferguson-Smith, M. A.</style></author><author><style face="normal" font="default" size="100%">Collins, V. P.</style></author><author><style face="normal" font="default" size="100%">Coleman, N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of pilocytic astrocytoma by comparative genomic hybridization</style></title><secondary-title><style face="normal" font="default" size="100%">Br J CancerBr J CancerBr J Cancer</style></secondary-title><alt-title><style face="normal" font="default" size="100%">British journal of cancer</style></alt-title><short-title><style face="normal" font="default" size="100%">British journal of cancerBritish journal of cancer</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Astrocytoma/*genetics/physiopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Brain Neoplasms/*genetics/physiopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosome Aberrations/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Duplication</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant, Newborn</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Nucleic Acid Hybridization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">6</style></number><volume><style face="normal" font="default" size="100%">82</style></volume><pages><style face="normal" font="default" size="100%">1218-22</style></pages><isbn><style face="normal" font="default" size="100%">0007-0920 (Print)0007-0920 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Very little is known about genetic abnormalities involved in the development of pilocytic astrocytoma, the most frequently occurring brain tumour of childhood. We have analysed 48 pilocytic astrocytoma specimens using comparative genomic hybridization. Only five of 41 tumours from children showed abnormalities detectable by comparative genomic hybridization, and in each case this represented gain of a single chromosome. Interestingly, two of seven tumours from adults showed abnormalities, which were multiple and relatively complex. Six of the seven tumours showing abnormalities were from female patients (two adults and four children). The most frequently detectable abnormality was gain of 9q34.1-qter, which was present in three cases (two adult and one paediatric).</style></abstract><accession-num><style face="normal" font="default" size="100%">10735509</style></accession-num><notes><style face="normal" font="default" size="100%">Sanoudou, DTingby, OFerguson-Smith, M ACollins, V PColeman, NengResearch Support, Non-U.S. Gov'tEngland2000/03/29 00:00Br J Cancer. 2000 Mar;82(6):1218-22. doi: 10.1054/bjoc.1999.1066.</style></notes><custom2><style face="normal" font="default" size="100%">2363345</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Pathology, University of Cambridge, UK.</style></auth-address></record></records></xml>