@article {45875,
	title = {Immunologic Dysregulation and Hypercoagulability as a Pathophysiologic Background in COVID-19 Infection and the Immunomodulating Role of Colchicine.},
	journal = {J Clin Med},
	volume = {10},
	year = {2021},
	month = {2021 Oct 31},
	abstract = {In 2020, SARS-COV-2 put health systems under unprecedented resource and manpower pressure leading to significant number of deaths. Expectedly, researchers sought to shed light on the pathophysiologic background of this novel disease (COVID-19) as well as to facilitate the design of effective therapeutic modalities. Indeed, early enough the pivotal role of inflammatory and thrombotic pathways in SARS-COV-2 infection has been illustrated. The purpose of this article is to briefly present the epidemiologic and clinical features of COVID-19, analyze the pathophysiologic importance of immunologic dysregulation and hypercoagulability in developing disease complications and finally to present an up-to-date systematic review of colchicine{\textquoteright}s immunomodulating capacity in view of hindering coronavirus complications.},
	issn = {2077-0383},
	doi = {10.3390/jcm10215128},
	author = {Vrachatis, Dimitrios A and Papathanasiou, Konstantinos A and Giotaki, Sotiria G and Raisakis, Konstantinos and Kossyvakis, Charalampos and Kaoukis, Andreas and Kolokathis, Fotis and Deftereos, Gerasimos and Iliodromitis, Konstantinos E and Avramides, Dimitrios and Bogossian, Harilaos and Siasos, Gerasimos and Giannopoulos, George and Reimers, Bernhard and Lansky, Alexandra and Tardif, Jean-Claude and Deftereos, Spyridon}
}
