<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deftereos, Spyridon G</style></author><author><style face="normal" font="default" size="100%">Siasos, Gerasimos</style></author><author><style face="normal" font="default" size="100%">Giannopoulos, Georgios</style></author><author><style face="normal" font="default" size="100%">Vrachatis, Dimitrios A</style></author><author><style face="normal" font="default" size="100%">Angelidis, Christos</style></author><author><style face="normal" font="default" size="100%">Giotaki, Sotiria G</style></author><author><style face="normal" font="default" size="100%">Gargalianos, Panagiotis</style></author><author><style face="normal" font="default" size="100%">Giamarellou, Helen</style></author><author><style face="normal" font="default" size="100%">Gogos, Charalampos</style></author><author><style face="normal" font="default" size="100%">Daikos, Georgios</style></author><author><style face="normal" font="default" size="100%">Lazanas, Marios</style></author><author><style face="normal" font="default" size="100%">Pagona Lagiou</style></author><author><style face="normal" font="default" size="100%">Saroglou, Georgios</style></author><author><style face="normal" font="default" size="100%">Sipsas, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Tsiodras, Sotirios</style></author><author><style face="normal" font="default" size="100%">Chatzigeorgiou, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Moussas, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Kotanidou, Anastasia</style></author><author><style face="normal" font="default" size="100%">Koulouris, Nikolaos</style></author><author><style face="normal" font="default" size="100%">Oikonomou, Evangelos</style></author><author><style face="normal" font="default" size="100%">Kaoukis, Andreas</style></author><author><style face="normal" font="default" size="100%">Kossyvakis, Charalampos</style></author><author><style face="normal" font="default" size="100%">Raisakis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Fountoulaki, Katerina</style></author><author><style face="normal" font="default" size="100%">Comis, Mihalis</style></author><author><style face="normal" font="default" size="100%">Tsiachris, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Sarri, Eleni</style></author><author><style face="normal" font="default" size="100%">Theodorakis, Andreas</style></author><author><style face="normal" font="default" size="100%">Martinez-Dolz, Luis</style></author><author><style face="normal" font="default" size="100%">Sanz-Sánchez, Jorge</style></author><author><style face="normal" font="default" size="100%">Reimers, Bernhard</style></author><author><style face="normal" font="default" size="100%">Stefanini, Giulio G</style></author><author><style face="normal" font="default" size="100%">Cleman, Michael</style></author><author><style face="normal" font="default" size="100%">Filippou, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Olympios, Christoforos D</style></author><author><style face="normal" font="default" size="100%">Pyrgakis, Vlasios N</style></author><author><style face="normal" font="default" size="100%">Goudevenos, John</style></author><author><style face="normal" font="default" size="100%">Hahalis, George</style></author><author><style face="normal" font="default" size="100%">Kolettis, Theofilos M</style></author><author><style face="normal" font="default" size="100%">Iliodromitis, Efstathios</style></author><author><style face="normal" font="default" size="100%">Tousoulis, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Stefanadis, Christodoulos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design.</style></title><secondary-title><style face="normal" font="default" size="100%">Hellenic J Cardiol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Hellenic J Cardiol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antirheumatic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Betacoronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical Laboratory Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Colchicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronavirus Infections</style></keyword><keyword><style  face="normal" font="default" size="100%">Covid-19</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19 Testing</style></keyword><keyword><style  face="normal" font="default" size="100%">Heart Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Pandemics</style></keyword><keyword><style  face="normal" font="default" size="100%">Pneumonia, Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">Randomized Controlled Trials as Topic</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Symptom Assessment</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 Jan-Feb</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">61</style></volume><pages><style face="normal" font="default" size="100%">42-45</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.

METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature &gt;37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2&lt;95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group.

RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations.

CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/32251729?dopt=Abstract</style></custom1></record></records></xml>