<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Giannopoulos, Georgios</style></author><author><style face="normal" font="default" size="100%">Kossyvakis, Charalampos</style></author><author><style face="normal" font="default" size="100%">Vrachatis, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Aggeli, Constadina</style></author><author><style face="normal" font="default" size="100%">Tsitsinakis, Georgios</style></author><author><style face="normal" font="default" size="100%">Letsas, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Tsiachris, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Tsoukala, Styliani</style></author><author><style face="normal" font="default" size="100%">Efremidis, Michalis</style></author><author><style face="normal" font="default" size="100%">Katritsis, Dimosthenis</style></author><author><style face="normal" font="default" size="100%">Deftereos, Spyridon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of cryoballoon and radiofrequency ablation for pulmonary vein isolation on left atrial function in patients with nonvalvular paroxysmal atrial fibrillation: A prospective randomized study (Cryo-LAEF study).</style></title><secondary-title><style face="normal" font="default" size="100%">J Cardiovasc Electrophysiol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Cardiovasc Electrophysiol</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Action Potentials</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Atrial Fibrillation</style></keyword><keyword><style  face="normal" font="default" size="100%">Atrial Function, Left</style></keyword><keyword><style  face="normal" font="default" size="100%">Catheter Ablation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cryosurgery</style></keyword><keyword><style  face="normal" font="default" size="100%">Echocardiography, Three-Dimensional</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece</style></keyword><keyword><style  face="normal" font="default" size="100%">Heart Rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Prospective Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary Veins</style></keyword><keyword><style  face="normal" font="default" size="100%">Recovery of Function</style></keyword><keyword><style  face="normal" font="default" size="100%">Recurrence</style></keyword><keyword><style  face="normal" font="default" size="100%">Time Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment Outcome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Jul</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">30</style></volume><pages><style face="normal" font="default" size="100%">991-998</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Isolation of the pulmonary veins (PVI) has become a mainstay in atrial fibrillation (AFib) therapy. Lesions in left atrial tissue lead to scar formation and this may affect left atrial function.

METHODS: Patients with paroxysmal AFib were randomly assigned in a 1:2 allocation scheme to radiofrequency (RF) ablation or cryoballoon. Real-time three-dimensional echocardiography was performed (under sinus rhythm in all cases) before ablation and at 1 and 3 months to evaluate the left atrial functional indices. The primary outcome measure was change in left atrial ejection fraction (LAEF) at 1 month.

RESULTS: 120 patients were randomized (80 to cryoballoon, 40 to RF). The absolute change in LAEF at 1 month was 4.0 (Q1-Q3, -0.1to 7.6)% in the cryoballoon group and -0.8 (Q1-Q3, -1.9 to 0.9)% in the RF group (P &lt; 0.001 for the comparison between groups). At 3 months, the corresponding changes were 6.7 (Q1-Q3, 3.4-11.2)% and 0.7 (Q1-Q3, -0.7 to 3.5)%, respectively (P &lt; 0.001). Overall, the rate of patients with lower LAEF at 3 months compared to baseline was 2.5% in the cryoballoon group and 32.5% in the RF group (P &lt; 0.001). AFib recurrence rate at 6 months was higher in patients with decreased LAEF (odds ratio, 6.2; 95% confidence interval, 2.0-19.5; P = 0.002).

CONCLUSION: The Cryo-LAEF study prospectively compared the effects of RF and cryoballoon ablation on left atrial function. Both at 1 and 3 months postablation, LAEF was either improved or stable in both ablation groups.</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/30938914?dopt=Abstract</style></custom1></record></records></xml>