<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Giannopoulos, Georgios</style></author><author><style face="normal" font="default" size="100%">Kossyvakis, Charalampos</style></author><author><style face="normal" font="default" size="100%">Panagopoulou, Vasiliki</style></author><author><style face="normal" font="default" size="100%">Tsiachris, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Doudoumis, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Mavri, Maria</style></author><author><style face="normal" font="default" size="100%">Vrachatis, Dimitrios</style></author><author><style face="normal" font="default" size="100%">Letsas, Konstantinos</style></author><author><style face="normal" font="default" size="100%">Efremidis, Michael</style></author><author><style face="normal" font="default" size="100%">Katsivas, Apostolos</style></author><author><style face="normal" font="default" size="100%">Lekakis, John</style></author><author><style face="normal" font="default" size="100%">Deftereos, Spyridon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Permanent pacemaker implantation in octogenarians with unexplained syncope and positive electrophysiologic testing.</style></title><secondary-title><style face="normal" font="default" size="100%">Heart Rhythm</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Heart Rhythm</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Bradycardia</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiac Pacing, Artificial</style></keyword><keyword><style  face="normal" font="default" size="100%">Electrophysiologic Techniques, Cardiac</style></keyword><keyword><style  face="normal" font="default" size="100%">Heart Block</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Pacemaker, Artificial</style></keyword><keyword><style  face="normal" font="default" size="100%">Syncope</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 May</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">694-699</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Syncope is a common problem in the elderly, and a permanent pacemaker is a therapeutic option when a bradycardic etiology is revealed. However, the benefit of pacing when no association of symptoms to bradycardia has been shown is not clear, especially in the elderly.

OBJECTIVE: The aim of this study was to evaluate the effect of pacing on syncope-free mortality in patients aged 80 years or older with unexplained syncope and &quot;positive&quot; invasive electrophysiologic testing (EPT).

METHODS: This was an observational study. A positive EPT for the purposes of this study was defined by at least 1 of the following: a corrected sinus node recovery time of &gt;525 ms, a basic HV interval of &gt;55 ms, detection of infra-Hisian block, or appearance of second-degree atrioventricular block on atrial decremental pacing at a paced cycle length of &gt;400 ms.

RESULTS: Among the 2435 screened patients, 228 eligible patients were identified, 145 of whom were implanted with a pacemaker. Kaplan-Meier analysis determined that time to event (syncope or death) was 50.1 months (95% confidence interval 45.4-54.8 months) with a pacemaker vs 37.8 months (95% confidence interval 31.3-44.4 months) without a pacemaker (log-rank test, P = .001). The 4-year time-dependent estimate of the rate of syncope was 12% vs 44% (P &lt; .001) and that of any-cause death was 41% vs 56% (P = .023), respectively. The multivariable odds ratio was 0.25 (95% confidence interval 0.15-0.40) after adjustment for potential confounders.

CONCLUSION: In patients with unexplained syncope and signs of sinus node dysfunction or impaired atrioventricular conduction on invasive EPT, pacemaker implantation was independently associated with longer syncope-free survival. Significant differences were also shown in the individual components of the primary outcome measure (syncope and death from any cause).</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/28089877?dopt=Abstract</style></custom1></record></records></xml>