<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Giannopoulos, Georgios</style></author><author><style face="normal" font="default" size="100%">Vrachatis, Dimitrios A</style></author><author><style face="normal" font="default" size="100%">Oudatzis, Georgios</style></author><author><style face="normal" font="default" size="100%">Paterakis, Georgios</style></author><author><style face="normal" font="default" size="100%">Angelidis, Christos</style></author><author><style face="normal" font="default" size="100%">Koutivas, Athanasios</style></author><author><style face="normal" font="default" size="100%">Sianos, Georgios</style></author><author><style face="normal" font="default" size="100%">Cleman, Michael W</style></author><author><style face="normal" font="default" size="100%">Filippatos, Gerasimos</style></author><author><style face="normal" font="default" size="100%">Lekakis, John</style></author><author><style face="normal" font="default" size="100%">Deftereos, Spyridon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Circulating Erythrocyte Microparticles and the Biochemical Extent of Myocardial Injury in ST Elevation Myocardial Infarction.</style></title><secondary-title><style face="normal" font="default" size="100%">Cardiology</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cardiology</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Area Under Curve</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell-Derived Microparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatine Kinase, MB Form</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythrocyte Count</style></keyword><keyword><style  face="normal" font="default" size="100%">Erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Multivariate Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardium</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">ST Elevation Myocardial Infarction</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin I</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">136</style></volume><pages><style face="normal" font="default" size="100%">15-20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVES: Red blood cell microparticles (RBCm) have potential adverse vascular effects and they have been shown to be elevated in ST elevation myocardial infarction (STEMI). The purpose of this study is to investigate their relationship with biochemical infarct size.

METHODS: RBCm were quantified with flow cytometry in blood drawn from 60 STEMI patients after a primary angioplasty. The creatine kinase-myocardial brain fraction (CK-MB) was measured at predefined time points and the area under the curve (AUC) was calculated.

RESULTS: RBCm count was correlated with CK-MB AUC (Spearman's ρ = 0.83, p &lt; 0.001). The CK-MB AUC values per RBCm quartile (lower to upper) were: 3,351 (2,452-3,608), 5,005 (4,450-5,424), 5,903 (4,862-10,594), and 8,406 (6,848-12,782) ng × h/ml, respectively. From lower to upper quartiles, the maximal troponin I values were: 42.2 (23.3-49.3), 49.6 (28.8-54.1), 59.2 (41.4-77.3), and 69.1 (48.0-77.5) ng/ml (p = 0.005). In multivariable analysis, RBCm remained a significant predictor of CK-MB AUC (standardized β = 0.63, adjusted p = 0.001).

CONCLUSIONS: Erythrocyte microparticles appear to be related to the total myocardial damage biomarker output. The exact pathophysiologic routes, if any, for this interaction remain to be identified. However, these results suggest that erythrocytes may be a - thus far virtually ignored - player in the pathogenesis of ischemic injury.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/27552820?dopt=Abstract</style></custom1></record></records></xml>