<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vavuranakis, Manolis</style></author><author><style face="normal" font="default" size="100%">Vrachatis, Dimitrios A</style></author><author><style face="normal" font="default" size="100%">Papaioannou, Theodore G</style></author><author><style face="normal" font="default" size="100%">Archontakis, Stefanos</style></author><author><style face="normal" font="default" size="100%">Kalogeras, Konstantinos I</style></author><author><style face="normal" font="default" size="100%">Kariori, Maria G</style></author><author><style face="normal" font="default" size="100%">Gafou, Anthi</style></author><author><style face="normal" font="default" size="100%">Moldovan, Carmen</style></author><author><style face="normal" font="default" size="100%">Tzamalis, Panagiotis</style></author><author><style face="normal" font="default" size="100%">Stefanadis, Christodoulos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Residual platelet reactivity after clopidogrel loading in patients with ST-elevation myocardial infarction undergoing an unexpectedly delayed primary percutaneous coronary intervention. - Impact on intracoronary thrombus burden and myocardial perfusion-.</style></title><secondary-title><style face="normal" font="default" size="100%">Circ J</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Circ J</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute coronary syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Angioplasty, Balloon, Coronary</style></keyword><keyword><style  face="normal" font="default" size="100%">Clopidogrel</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronary Circulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronary Thrombosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardial Infarction</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet Aggregation Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Ticlopidine</style></keyword><keyword><style  face="normal" font="default" size="100%">Time Factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">75</style></volume><pages><style face="normal" font="default" size="100%">2105-12</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: Residual platelet reactivity (RPR) after clopidogrel loading, measured by the VerifyNow assay, has been shown to predict 12-month clinical events in patients with acute coronary syndromes. However, links between coronary angiographic findings and outcome in patients with ST-elevation myocardial infarction (STEMI), with RPR have not been reported. We investigated whether RPR is associated with the amount of intracoronary thrombus burden (TB) in patients with STEMI undergoing unexpectedly-delayed primary percutaneous coronary intervention (pPCI). Moreover, we evaluated whether RPR might influence coronary flow and myocardial perfusion immediately post-pPCI.

METHODS AND RESULTS: The VerifyNow assay was used to determine RPR after clopidogrel loading, expressed in P2Y12-Reaction-Units (PRU). Intracoronary-TB was angiographically estimated and stratified as TB-Grade-A, -B and -C. Thrombolysis In Myocardial Infarction (TIMI) flow and Myocardial Blush (MB) were also estimated post-PCI. A total of 74 consecutive patients who presented with STEMI were enrolled in the study. Patients with greater TB presented significantly higher PRU-levels (174.1 ± 91.5, 196.23 ± 113.4 and 252.8 ± 107.8 for TB-Grade A, B and C, respectively; P=0.044). PRU-levels &gt;251.5 were shown to predict Large-TB (LTB; TB-Grade-C) (sensitivity=57.9%; specificity=77.8%; P=0.014). Impaired TIMI-flow and MB after PCI were significantly associated with higher PRU-levels (P &lt; 0.001).

CONCLUSIONS: Among the studied patients, those with a higher RPR after clopidogrel loading presented larger intracoronary TB, worse post-PCI myocardial flow and perfusion.</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21712606?dopt=Abstract</style></custom1></record></records></xml>