@article {Kaloudis2009b,
	title = {{Photolabile N-hydroxypyrid-2(1H)-one derivatives of guanine nucleosides: a new method for independent guanine radical generation}},
	journal = {Org. Biomol. Chem.},
	volume = {7},
	number = {23},
	year = {2009},
	pages = {{\textendash}},
	abstract = {One-electron oxidized guanine is an important reactive intermediate in the formation of oxidatively generated damage in DNA and a variety of methods have been utilized for the abstraction of a single electron from the guanine moiety. In this study, an alternative approach for the site specific, independent generation of the guanine radical, utilizing N-hydroxypyrid-2(1H)-one as a photolabile modifier of guanine, is proposed. Novel photolabile 6-[(1-oxido-2-pyridinyl)oxo]-6-deoxy- and 2',6-dideoxy-guanosine derivatives capable of generating the neutral guanine radical (G(-H) {\textbullet}) upon photolysis were synthesized and characterized. The generation of G(-H) proceeds through homolysis of the N-O bond and was confirmed through continuous photolysis product analysis and trapping studies, as well as laser flash photolysis experiments. {\textcopyright} The Royal Society of Chemistry 2009.},
	issn = {1477-0520},
	doi = {10.1039/b909138f},
	url = {http://dx.doi.org/10.1039/b909138f http://xlink.rsc.org/?DOI=b909138f},
	author = {Kaloudis, Panagiotis and Paris, Cecilia and Vrantza, Despoina and Encinas, Susana and P{\'e}rez-Ruiz, Raul and Miranda, Miguel A. and Gimisis, Thanasis and Perez-Ruiz, Raul and Miranda, Miguel A. and Gimisis, Thanasis}
}
