<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kaloudis, Panagiotis</style></author><author><style face="normal" font="default" size="100%">Paris, Cecilia</style></author><author><style face="normal" font="default" size="100%">Vrantza, Despoina</style></author><author><style face="normal" font="default" size="100%">Encinas, Susana</style></author><author><style face="normal" font="default" size="100%">Pérez-Ruiz, Raul</style></author><author><style face="normal" font="default" size="100%">Miranda, Miguel A.</style></author><author><style face="normal" font="default" size="100%">Gimisis, Thanasis</style></author><author><style face="normal" font="default" size="100%">Perez-Ruiz, Raul</style></author><author><style face="normal" font="default" size="100%">Miranda, Miguel A.</style></author><author><style face="normal" font="default" size="100%">Gimisis, Thanasis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">{Photolabile N-hydroxypyrid-2(1H)-one derivatives of guanine nucleosides: a new method for independent guanine radical generation}</style></title><secondary-title><style face="normal" font="default" size="100%">Org. Biomol. Chem.</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1039/b909138f http://xlink.rsc.org/?DOI=b909138f</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">23</style></number><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">–</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">One-electron oxidized guanine is an important reactive intermediate in the formation of oxidatively generated damage in DNA and a variety of methods have been utilized for the abstraction of a single electron from the guanine moiety. In this study, an alternative approach for the site specific, independent generation of the guanine radical, utilizing N-hydroxypyrid-2(1H)-one as a photolabile modifier of guanine, is proposed. Novel photolabile 6-[(1-oxido-2-pyridinyl)oxo]-6-deoxy- and 2′,6-dideoxy-guanosine derivatives capable of generating the neutral guanine radical (G(-H) •) upon photolysis were synthesized and characterized. The generation of G(-H) proceeds through homolysis of the N-O bond and was confirmed through continuous photolysis product analysis and trapping studies, as well as laser flash photolysis experiments. © The Royal Society of Chemistry 2009.</style></abstract></record></records></xml>