@article {11583,
	title = {The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle.},
	journal = {Exp Gerontol},
	volume = {47},
	year = {2012},
	month = {2012 Jun},
	pages = {417-24},
	abstract = {Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p<0.05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO(2max) and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p<0.05). Our data suggest that moderate levels of regular physical activity increases a larger number of mitochondrial biogenesis-related gene expressions in young individuals than in aged subjects. Mitochondrial fission is impaired by aging and could be one of the most sensitive markers of the age-associated decline in the adaptive response to physical activity.},
	keywords = {Adult, Aged, Aging, Exercise, Gene Expression Regulation, Humans, Male, Middle Aged, Mitochondria, Muscle, Mitochondrial Proteins, Muscle Proteins, Muscle, Skeletal, Oxygen consumption, Real-Time Polymerase Chain Reaction, RNA, Messenger, Young Adult},
	issn = {1873-6815},
	doi = {10.1016/j.exger.2012.03.004},
	author = {Bori, Zoltan and Zhao, Zhongfu and Koltai, Erika and Fatouros, Ioannis G and Jamurtas, Athanasios Z and Douroudos, Ioannis I and Terzis, Gerasimos and Chatzinikolaou, Athanasios and Sovatzidis, Apostolos and Draganidis, Dimitrios and Boldogh, Istvan and Radak, Zsolt}
}
