<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Radak, Zsolt</style></author><author><style face="normal" font="default" size="100%">Bori, Zoltan</style></author><author><style face="normal" font="default" size="100%">Koltai, Erika</style></author><author><style face="normal" font="default" size="100%">Fatouros, Ioannis G</style></author><author><style face="normal" font="default" size="100%">Jamurtas, Athanasios Z</style></author><author><style face="normal" font="default" size="100%">Douroudos, Ioannis I</style></author><author><style face="normal" font="default" size="100%">Terzis, Gerasimos</style></author><author><style face="normal" font="default" size="100%">Nikolaidis, Michalis G</style></author><author><style face="normal" font="default" size="100%">Chatzinikolaou, Athanasios</style></author><author><style face="normal" font="default" size="100%">Sovatzidis, Apostolos</style></author><author><style face="normal" font="default" size="100%">Kumagai, Shuzo</style></author><author><style face="normal" font="default" size="100%">Naito, Hisahi</style></author><author><style face="normal" font="default" size="100%">Boldogh, Istvan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle.</style></title><secondary-title><style face="normal" font="default" size="100%">Free Radic Biol Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Free Radic. Biol. Med.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Base Sequence</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Glycosylases</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA Primers</style></keyword><keyword><style  face="normal" font="default" size="100%">Exercise</style></keyword><keyword><style  face="normal" font="default" size="100%">Guanine</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle, Skeletal</style></keyword><keyword><style  face="normal" font="default" size="100%">Reverse Transcriptase Polymerase Chain Reaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011 Jul 15</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">51</style></volume><pages><style face="normal" font="default" size="100%">417-23</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">8-Oxo-7,8-dihydroguanine (8-oxoG) accumulates in the genome over time and is believed to contribute to the development of aging characteristics of skeletal muscle and various aging-related diseases. Here, we show a significantly increased level of intrahelical 8-oxoG and 8-oxoguanine-DNA glycosylase (OGG1) expression in aged human skeletal muscle compared to that of young individuals. In response to exercise, the 8-oxoG level was lastingly elevated in sedentary young and old subjects, but returned rapidly to preexercise levels in the DNA of physically active individuals independent of age. 8-OxoG levels in DNA were inversely correlated with the abundance of acetylated OGG1 (Ac-OGG1), but not with total OGG1, apurinic/apyrimidinic endonuclease 1 (APE1), or Ac-APE1. The actual Ac-OGG1 level was linked to exercise-induced oxidative stress, as shown by changes in lipid peroxide levels and expression of Cu,Zn-SOD, Mn-SOD, and SIRT3, as well as the balance between acetyltransferase p300/CBP and deacetylase SIRT1, but not SIRT6 expression. Together these data suggest that that acetylated form of OGG1, and not OGG1 itself, correlates inversely with the 8-oxoG level in the DNA of human skeletal muscle, and the Ac-OGG1 level is dependent on adaptive cellular responses to physical activity, but is age independent.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21569841?dopt=Abstract</style></custom1></record></records></xml>